Research workbench
Crystal structure of beta-CATENIN/ICAT helical DOMAIN/UNPHOSPHORYLATED apc R3
Analyse Crystal structure of beta-CATENIN/ICAT helical DOMAIN/UNPHOSPHORYLATED apc R3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T08
- Type
- protein
- Length
- 571 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin; Beta-catenin-interacting protein 1; Adenomatous polyposis COLI protein
- UniProt
- P35222, Q9NSA3, P25054
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-catenin | protein | 510 | 75% helix, 0% strand | P35222 |
| B | Beta-catenin-interacting protein 1 | protein | 46 | 76% helix, 0% strand | Q9NSA3 |
| C | Adenomatous polyposis COLI protein | protein | 15 | 0% helix, 0% strand | P25054 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.54 | 0.78 | 34 | empty |
| 2 | 51 | 0.29 | 0.75 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–C · 961 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 676 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1T08 · Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 · the same entry in another collection · chain A against A, TM-score 1.00
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NSA3 · AlphaFold monomer V2.0 prediction for beta-catenin-interacting protein 1 (Q9NSA3) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35222
- Every structure of UniProt Q9NSA3
- Every structure of UniProt P25054
- Elsewhere: RCSB PDB 1T08 · PDBe 1T08 · UniProt P35222 · UniProt Q9NSA3 · UniProt P25054
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