Research workbench
Human vinculin head domain VH1, residues 1-258, in complex with human TALIN'S vinculin binding site 1, residues 607-636
Analyse Human vinculin head domain VH1, residues 1-258, in complex with human TALIN'S… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SYQ
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vinculin isoform vcl; Talin 1
- UniProt
- P18206, Q9Y490
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vinculin isoform vcl | protein | 259 | 81% helix, 1% strand | P18206 |
| B | Talin 1 | protein | 25 | 72% helix, 0% strand | Q9Y490 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.44 | 0.78 | 15 | empty |
| 2 | 57 | 0.41 | 0.81 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1182 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1SYQ · Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin… · the same entry in another collection · chain A against A, TM-score 1.00
- P18206 · AlphaFold monomer V2.0 prediction for vinculin (P18206) · a predicted model of the same protein · chain A against A, TM-score 0.83
- Q9Y490 · AlphaFold monomer V2.0 prediction for talin-1 (Q9Y490) · a predicted model of the same protein · chain B against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18206
- Every structure of UniProt Q9Y490
- Elsewhere: RCSB PDB 1SYQ · PDBe 1SYQ · UniProt P18206 · UniProt Q9Y490
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