UniProt P18206
Vinculin (P18206)
Vinculin (UniProt P18206): 65 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 301 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18206
- Protein
- Vinculin
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 301 · 42 records with a druggable one
Structures
66 records of P18206 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RKC | Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969) | x-ray diffraction | A | — | 3 (best 0.59) |
| 1RKC | Human vinculin head (1-258) in complex with TALIN'S vinculin binding site 3 (residues 1944-1969) | x-ray diffraction | A | — | 3 (best 0.59) |
| 1RKE | Human vinculin head (1-258) in complex with human vinculin tail (879-1066) | x-ray diffraction | A, B | — | 4 (best 0.59) |
| 1RKE | Human vinculin head (1-258) in complex with human vinculin tail (879-1066) | x-ray diffraction | A, B | — | 4 (best 0.59) |
| 1SYQ | Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site… | x-ray diffraction | A | — | 2 (best 0.44) |
| 1SYQ | Human vinculin head domain VH1, residues 1-258, in complex with human TALIN'S vinculin binding site… | x-ray diffraction | A | — | 2 (best 0.44) |
| 1TR2 | Crystal structure of human full-length vinculin (residues 1-1066) | x-ray diffraction | A, B | — | 20 (best 0.85) |
| 1TR2 | Crystal structure of human full-length vinculin (residues 1- 1066) | x-ray diffraction | A, B | — | 20 (best 0.85) |
| 1YDI | Human vinculin head domain (VH1, 1-258) in complex with human alpha-ACTININ'S vinculin-binding site… | x-ray diffraction | — | — | |
| 2GWW | Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding… | x-ray diffraction | A | — | 3 (best 0.57) |
| 2GWW | Human vinculin (head domain, VH1, residues 1-258) in complex with SHIGELLA'S ipaa vinculin binding… | x-ray diffraction | A | — | 3 (best 0.57) |
| 2HSQ | Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding… | x-ray diffraction | A | — | 3 (best 0.55) |
| 2HSQ | Human vinculin (head domain, VH1, residues 1-258) in complex with SHIGELLA'S ipaa vinculin binding… | x-ray diffraction | A | — | 3 (best 0.55) |
| 2IBF | Human vinculin's head domain (Vh1, residues 1-258) in complex with two vinculin binding sites of… | x-ray diffraction | A | — | 3 (best 0.41) |
| 2IBF | Human VINCULIN'S head domain (VH1, residues 1-258) in complex with two vinculin binding sites of… | x-ray diffraction | A | — | 3 (best 0.41) |
| 3JBK | Cryo-EM reconstruction of the metavinculin-actin interface | electron microscopy | M | — | 3 (best 0.66) |
| 3JBK | Cryo-EM reconstruction of the metavinculin-actin interface | electron microscopy | M | — | 3 (best 0.66) |
| 3MYI | Human metavinculin tail domain | x-ray diffraction | A | — | 1 (best 0.31) |
| 3MYI | Human metavinculin tail domain | x-ray diffraction | A | — | 1 (best 0.31) |
| 3RF3 | Shigella IpaA-VBS3 in complex with human vinculin | x-ray diffraction | A, B | — | 6 (best 0.74) |
| 3RF3 | Shigella ipaa-VBS3 in complex with human vinculin | x-ray diffraction | A, B | — | 6 (best 0.74) |
| 3S90 | Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues… | x-ray diffraction | A, B | — | 3 (best 0.52) |
| 3S90 | Human vinculin head domain VH1 (residues 1-252) in complex with murine talin (VBS33; residues… | x-ray diffraction | A, B | — | 3 (best 0.52) |
| 3TJ5 | human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the… | x-ray diffraction | A | — | 4 (best 0.49) |
| 3TJ5 | Human vinculin head domain (VH1, residues 1-258) in complex with the vinculin binding site of the… | x-ray diffraction | A | — | 4 (best 0.49) |
| 3TJ6 | human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the… | x-ray diffraction | A | — | 2 (best 0.64) |
| 3TJ6 | Human vinculin head domain (VH1, residues 1-258) in complex with the vinculin binding site of the… | x-ray diffraction | A | — | 2 (best 0.64) |
| 3VF0 | Raver1 in complex with metavinculin L954 deletion mutant | x-ray diffraction | A | — | 1 (best 0.54) |
| 3VF0 | RAVER1 in complex with metavinculin L954 deletion mutant | x-ray diffraction | A | — | 1 (best 0.54) |
| 4DJ9 | Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50… | x-ray diffraction | A | — | 2 (best 0.48) |
| 4DJ9 | Human vinculin head domain VH1 (residues 1-258) in complex with the talin vinculin binding site 50… | x-ray diffraction | A | — | 2 (best 0.48) |
| 4EHP | Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin… | x-ray diffraction | A | — | 1 (best 0.70) |
| 4EHP | Crystal structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin… | x-ray diffraction | A | — | 1 (best 0.70) |
| 4LN2 | The second SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin | x-ray diffraction | B | — | — |
| 4LN2 | The second SH3 domain from CAP/PONSIN in complex with proline rich peptide from vinculin | x-ray diffraction | B | — | — |
| 4LNP | The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin | x-ray diffraction | B | — | — |
| 4LNP | The first SH3 domain from CAP/PONSIN in complex with proline rich peptide from vinculin | x-ray diffraction | B | — | — |
| 4PR9 | Human Vinculin (residues 891-1066) in complex with PIP | x-ray diffraction | A, B, C, D, E, F | PIO | 10 (best 0.53) |
| 4PR9 | Human vinculin (residues 891-1066) in complex with pip | x-ray diffraction | A, B, C, D, E, F | PIO | 10 (best 0.53) |
| 5L0C | Human metavinculin (residues 959-1134) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO, PO4 | 4 (best 0.82) |
| 5L0C | Human metavinculin (residues 959-1134) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO, PO4 | 4 (best 0.82) |
| 5L0D | Human Metavinculin(residues 959-1130) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO | 6 (best 0.75) |
| 5L0D | Human METAVINCULIN(RESIDUES 959-1130) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO | 6 (best 0.75) |
| 5L0F | Human metavinculin quadruple mutant (residues 959-1134) | x-ray diffraction | A, B | — | 2 (best 0.62) |
| 5L0F | Human metavinculin quadruple mutant (residues 959-1134) | x-ray diffraction | A, B | — | 2 (best 0.62) |
| 5L0G | Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO | 5 (best 0.77) |
| 5L0G | Human metavinculin mvt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2 | x-ray diffraction | A, B, C, D | PIO | 5 (best 0.77) |
| 5L0H | Human metavinculin MVt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with… | x-ray diffraction | A | PIO, PO4 | — |
| 5L0H | Human metavinculin mvt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with… | x-ray diffraction | A | PIO, PO4 | — |
| 5L0I | Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134) | x-ray diffraction | A | NA | — |
| 5L0I | Human metavinculin mvt R975W cardiomyopathy-associated mutant (residues 959-1134) | x-ray diffraction | A | NA | — |
| 5L0J | Human vinculin R903Q, D907R, R910T mutant(residues 891-1066) | x-ray diffraction | A, B | — | 4 (best 0.55) |
| 5L0J | Human vinculin R903Q, D907R, R910T MUTANT(RESIDUES 891-1066) | x-ray diffraction | A, B | — | 4 (best 0.55) |
| 6FUY | Crystal structure of human full-length vinculin-T12-A974K (residues 1-1066) | x-ray diffraction | A | CA | 14 (best 0.81) |
| 6FUY | Crystal structure of human full-length vinculin-T12-A974K (residues 1- 1066) | x-ray diffraction | A | CA | 14 (best 0.81) |
| 6UPW | Metavinculin ABD-F-actin complex | electron microscopy | L, M | — | 6 (best 0.58) |
| 6UPW | Metavinculin abd-F-actin complex | electron microscopy | L, M | — | — |
| 7KTT | Cryogenic electron microscopy model of full-length human metavinculin | electron microscopy | A | — | 16 (best 0.80) |
| 7KTT | Cryogenic electron microscopy model of full-length human metavinculin | electron microscopy | A | — | — |
| 7KTU | Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 1 | electron microscopy | A | — | 15 (best 0.83) |
6 records more on the page itself.
Ligands
Experiment against prediction
- 1TR2 chain B against the predicted model P18206: TM-score 0.98, RMSD 1.65 Å
- 1TR2 chain B against the predicted model P18206: TM-score 0.98, RMSD 1.65 Å
- 5L0G chain C against the predicted model P18206: TM-score 0.98, RMSD 0.99 Å
- 5L0G chain C against the predicted model P18206: TM-score 0.98, RMSD 0.99 Å
- 5L0H chain A against the predicted model P18206: TM-score 0.98, RMSD 0.94 Å
- 5L0H chain A against the predicted model P18206: TM-score 0.98, RMSD 0.94 Å
- 5L0D chain C against the predicted model P18206: TM-score 0.97, RMSD 0.86 Å
- 5L0D chain C against the predicted model P18206: TM-score 0.97, RMSD 0.86 Å
- 5L0J chain B against the predicted model P18206: TM-score 0.97, RMSD 0.98 Å
- 5L0J chain B against the predicted model P18206: TM-score 0.97, RMSD 0.98 Å
Elsewhere
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