MolNFT v1 · #125152 · protein
Human vinculin R903Q, D907R, R910T MUTANT(RESIDUES 891-1066)
5L0J: “Human vinculin R903Q, D907R, R910T MUTANT(RESIDUES 891-1066)”. X-ray diffraction, 4 pockets (best druggability 0.55). MolNFT v1 #125152 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5L0J
- Type
- protein
- Length
- 331 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vinculin
- UniProt
- P18206
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vinculin | protein | 165 | 73% helix, 1% strand | P18206 |
| B | Vinculin | protein | 166 | 70% helix, 2% strand | P18206 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.55 | 0.85 | 18 | empty |
| 2 | 178 | 0.48 | 0.76 | 20 | empty |
| 3 | 84 | 0.34 | 0.74 | 12 | empty |
| 4 | 73 | 0.34 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 703 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18206
- Elsewhere: RCSB PDB 5L0J · PDBe 5L0J · UniProt P18206
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.