Research workbench
Circular permuted streptavidin E51/A46 in complex with biotin
Analyse Circular permuted streptavidin E51/A46 in complex with biotin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SWG
- Type
- protein
- Length
- 463 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Circularly permuted core-streptavidin E51/A46
- UniProt
- P22629
- Ligands
- BTN
- Pockets
- 7 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Circularly permuted core-streptavidin E51/A46 | protein | 112 | 5% helix, 61% strand | P22629 |
| C | Circularly permuted core-streptavidin E51/A46 | protein | 126 | 12% helix, 57% strand | P22629 |
| D | Circularly permuted core-streptavidin E51/A46 | protein | 113 | 5% helix, 61% strand | P22629 |
Ligands and binding sites
- BTN · Biotin · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.62 | 0.80 | 45 | empty |
| 2 | 158 | 0.53 | 0.80 | 26 | empty |
| 3 | 147 | 0.52 | 0.80 | 24 | empty |
| 4 | 107 | 0.49 | 0.81 | 21 | BTN |
| 5 | 113 | 0.47 | 0.79 | 19 | BTN |
Interfaces
6 interfaces between chains.
- C–D · 1678 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 1627 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 436 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 432 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 219 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1SWG · Circular permuted streptavidin E51/A46 in complex with biotin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 1SWG · PDBe 1SWG · UniProt P22629
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.