Research workbench
Crystal structure of talin rod 482-655
Analyse Crystal structure of talin rod 482-655 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SJ7
- Type
- protein
- Length
- 503 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Talin 1
- UniProt
- P26039
- Ligands
- PT
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Talin 1 | protein | 167 | 75% helix, 0% strand | P26039 |
| B | Talin 1 | protein | 170 | 76% helix, 0% strand | P26039 |
| C | Talin 1 | protein | 166 | 72% helix, 0% strand | P26039 |
Ligands and binding sites
- PT · Platinum (II) ion · metal · 7 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.77 | 0.89 | 38 | empty |
| 2 | 627 | 0.72 | 0.80 | 70 | empty |
| 3 | 127 | 0.52 | 0.81 | 22 | empty |
| 4 | 125 | 0.48 | 0.79 | 19 | empty |
| 5 | 61 | 0.47 | 0.84 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1090 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 258 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 189 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26039
- Elsewhere: RCSB PDB 1SJ7 · PDBe 1SJ7 · UniProt P26039
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