UniProt P26039
Talin-1 (P26039)
Talin-1 (UniProt P26039): 69 experimental structures on GenesisL1, 4 ligands bound, 74 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P26039
- Protein
- Talin-1
- Experimental structures
- 69
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 74 · 7 records with a druggable one
Structures
69 records of P26039 in the MolNFT archive: 69 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SJ7 | Crystal Structure of Talin Rod 482-655 | x-ray diffraction | A, B, C | — | — |
| 1SJ7 | Crystal structure of talin rod 482-655 | x-ray diffraction | A, B, C | — | — |
| 1SJ8 | Solution Structure of the R1R2 Domains of Talin | x-ray diffraction | A | — | — |
| 1SJ8 | Solution structure of the R1R2 domains of talin | x-ray diffraction | A | — | — |
| 1T01 | Vinculin complexed with the VBS1 helix from talin | x-ray diffraction | B | — | — |
| 1T01 | Vinculin complexed with the VBS1 helix from talin | x-ray diffraction | B | — | — |
| 1U89 | Solution structure of VBS2 fragment of talin | solution nmr | A | — | — |
| 1U89 | Solution structure of VBS2 fragment of talin | solution nmr | A | — | — |
| 1Y19 | Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 1Y19 | Structural basis for phosphatidylinositol phosphate kinase type I- gamma binding to talin at focal… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 1ZW3 | Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-1652 | x-ray diffraction | B | — | — |
| 1ZW3 | Vinculin head (0-258) in complex with the talin rod residues 1630-1652 | x-ray diffraction | B | — | — |
| 2B0H | Solution structure of VBS3 fragment of talin | solution nmr | A | — | — |
| 2B0H | Solution structure of VBS3 fragment of talin | solution nmr | A | — | — |
| 2G35 | NMR structure of talin-PTB in complex with PIPKI | solution nmr | A | — | — |
| 2G35 | NMR structure of talin-ptb in complex with pipki | solution nmr | A | — | — |
| 2JSW | Solution Structure of the R13 Domain of Talin | solution nmr | A | — | — |
| 2JSW | Solution structure of the R13 domain of talin | solution nmr | A | — | — |
| 2KBB | Solution Structure of the R9 Domain of Talin | solution nmr | A | — | — |
| 2KBB | Solution structure of the R9 domain of talin | solution nmr | A | — | — |
| 2KC2 | NMR structure of the F1 domain (residues 86-202) of the talin | solution nmr | A | — | — |
| 2KC2 | NMR structure of the F1 domain (residues 86-202) of the talin | solution nmr | A | — | — |
| 2KGX | HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 | solution nmr | A | — | — |
| 2KGX | Haddock structure of the talin F3 domain in complex with talin 1655- 1822 | solution nmr | A | — | — |
| 2KVP | Solution Structure of the R10 Domain of Talin | solution nmr | A | — | — |
| 2KVP | Solution structure of the R10 domain of talin | solution nmr | A | — | — |
| 2L10 | Solution Structure of the R6 Domain of Talin | solution nmr | A | — | — |
| 2L10 | Solution structure of the R6 domain of talin | solution nmr | A | — | — |
| 2L7A | Solution Structure of the R3 Domain of Talin | solution nmr | A | — | — |
| 2L7A | Solution structure of the R3 domain of talin | solution nmr | A | — | — |
| 2L7N | Solution Structure of the R5 Domain of Talin | solution nmr | A | — | — |
| 2L7N | Solution structure of the R5 domain of talin | solution nmr | A | — | — |
| 2LQG | Solution Structure of the R4 domain of talin | solution nmr | A | — | — |
| 2LQG | Solution structure of the R4 domain of talin | solution nmr | A | — | — |
| 2QDQ | Crystal structure of the talin dimerisation domain | x-ray diffraction | A, B | — | — |
| 2QDQ | Crystal structure of the talin dimerisation domain | x-ray diffraction | A, B | — | — |
| 2X0C | Crystal Structure of the R7R8 domains of Talin | x-ray diffraction | A | — | — |
| 2X0C | Structure of the talin rod residues 1359-1659 | x-ray diffraction | A | — | — |
| 3DYJ | Crystal Structure of the R11R12 Domains of Talin | x-ray diffraction | A, B | — | — |
| 3DYJ | Crystal structure of the R11R12 domains of talin | x-ray diffraction | A, B | — | — |
| 3IVF | Crystal structure of the talin head FERM domain | x-ray diffraction | A | — | — |
| 3IVF | Crystal structure of the talin head ferm domain | x-ray diffraction | A | — | — |
| 3S90 | Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues… | x-ray diffraction | C, D | — | — |
| 3S90 | Human vinculin head domain VH1 (residues 1-252) in complex with murine talin (VBS33; residues… | x-ray diffraction | C, D | — | — |
| 4F7G | Crystal structure of talin autoinhibition complex | x-ray diffraction | A, B | — | — |
| 4F7G | Crystal structure of talin autoinhibition complex | x-ray diffraction | A, B | — | — |
| 4W8P | Crystal structure of RIAM TBS1 in complex with talin R7R8 domains | x-ray diffraction | A | — | 1 (best 0.37) |
| 4W8P | Crystal structure of riam TBS1 in complex with talin R7R8 domains | x-ray diffraction | A | — | — |
| 5FZT | The crystal structure of R7R8 in complex with a DLC1 fragment. | x-ray diffraction | A | — | — |
| 5IC0 | Structural analysis of a talin triple domain module | x-ray diffraction | A | — | — |
| 5IC0 | Structural analysis of a talin triple domain module | x-ray diffraction | A | — | — |
| 5IC1 | Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant | x-ray diffraction | A | — | — |
| 5NL1 | Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512 | x-ray diffraction | A, B, C, D, E, F | CL, SO4 | 15 (best 0.87) |
| 5NL1 | Shigella ipaa-VBS3/TBS in complex with the talin VBS1 domain 488-512 | x-ray diffraction | A, B, C, D, E, F | CL, SO4 | — |
| 6BA6 | Solution structure of RAP1B/TALIN complex | solution nmr | A | — | — |
| 6MFS | Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol… | x-ray diffraction | A | PIO, PO4 | — |
| 6MFS | Mouse TALIN1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol… | x-ray diffraction | A | PIO, PO4 | — |
| 6TWN | Crystal structure of Talin1 R7R8 in complex with CDK1 (206-223) | x-ray diffraction | A, B | — | — |
| 6TWN | Crystal structure of TALIN1 R7R8 in complex with CDK1 (206-223) | x-ray diffraction | A, B | — | — |
| 6VGU | Crystal structure of FERM-folded talin head domain bound to the NPLY motif of beta3-integrin | x-ray diffraction | A | — | — |
9 records more on the page itself.
Ligands
Experiment against prediction
- 8VDP chain A against the predicted model P42212: TM-score 0.06, RMSD 5.15 Å
- 8VDQ chain A against the predicted model P42212: TM-score 0.05, RMSD 6.05 Å
- 6VGU chain A against the predicted model O54890: TM-score 0.27, RMSD 6.89 Å
- 6VGU chain A against the predicted model O54890: TM-score 0.27, RMSD 6.89 Å
- 8FSO chain A against the predicted model Q9Z0T9: TM-score 0.27, RMSD 7.39 Å
- 8T0A chain A against the predicted model P11835: TM-score 0.26, RMSD 6.38 Å
- 8FSE chain A against the predicted model P11835: TM-score 0.26, RMSD 6.72 Å
- 8FSE chain B against the predicted model P11835: TM-score 0.25, RMSD 6.41 Å
Elsewhere
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