ARF1[DELTA 1-17]-GDP-mg in complex with brefeldin a and a SEC7 domain

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 10% strand (DSSP).

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · chains A
• AFB · 1,6,7,8,9,11A,12,13,14,14A-decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one · ligand · chains A, E
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–E · 1439 Ų buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (artifact).

Compared structures

• 1S9D · ARF1[DELTA 1-17]-GDP-mg in complex with brefeldin a and a SEC7 domain · the same entry in another collection · chain E against E, TM-score 1.00
• Q99418 · AlphaFold monomer V2.0 prediction for cytohesin-2 (Q99418) · a predicted model of the same protein · chain E against A, TM-score 0.90
• P84080 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor 1 (P84080) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P84080
• Every structure of UniProt Q99418
• Elsewhere: RCSB PDB 1S9D · PDBe 1S9D · UniProt P84080 · UniProt Q99418