Research workbench
Crystal structure of FKBP52 C-terminal domain complex with the C-terminal peptide meevd of HSP90
Analyse Crystal structure of FKBP52 C-terminal domain complex with the C-terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QZ2
- Type
- protein
- Length
- 865 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FK506-binding protein 4; 5-mer peptide from heat shock protein HSP 90
- EC
- 5.2.1.8
- UniProt
- Q02790, P08238
- Pockets
- 12 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | FK506-binding protein 4 (EC 5.2.1.8) | protein | 285 | 54% helix, 16% strand | Q02790 |
| G, H | 5-mer peptide from heat shock protein HSP 90 | protein | 5 | 0% helix, 0% strand | P08238 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 289 | 0.71 | 0.85 | 31 | empty |
| 2 | 330 | 0.70 | 0.83 | 30 | empty |
| 3 | 351 | 0.62 | 0.78 | 31 | empty |
| 4 | 452 | 0.60 | 0.75 | 49 | empty |
| 5 | 307 | 0.55 | 0.75 | 32 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1098 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 1041 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 676 Ų buried · 2 hydrogen bonds · protein-protein
- A–G · 240 Ų buried · 6 hydrogen bonds · protein-protein
- B–H · 229 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1QZ2 · Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD… · the same entry in another collection · chain H against H, TM-score 1.00
- Q02790 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP4 (Q02790) · a predicted model of the same protein · chain B against A, TM-score 0.89
- P08238 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-beta (P08238) · a predicted model of the same protein · chain G against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02790
- Every structure of UniProt P08238
- Elsewhere: RCSB PDB 1QZ2 · PDBe 1QZ2 · UniProt Q02790 · UniProt P08238
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