Research workbench
Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex
Analyse Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QBK
- Type
- protein
- Length
- 1,070 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Karyopherin BETA2; Ran
- UniProt
- Q92973, P62826
- Ligands
- GNP, MG
- Pockets
- 15 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Karyopherin BETA2 | protein | 880 | 58% helix, 0% strand | Q92973 |
| C | Ran | protein | 190 | 18% helix, 21% strand | P62826 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains C
- MG · Magnesium ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 757 | 0.87 | 0.90 | 80 | empty |
| 2 | 381 | 0.82 | 0.91 | 49 | empty |
| 3 | 757 | 0.75 | 0.80 | 69 | empty |
| 4 | 249 | 0.72 | 0.86 | 40 | empty |
| 5 | 498 | 0.71 | 0.81 | 41 | empty |
Interfaces
1 interface between chains.
- B–C · 2206 Ų buried · 32 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 27 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P62826
- Elsewhere: RCSB PDB 1QBK · PDBe 1QBK · UniProt Q92973 · UniProt P62826
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.