Research workbench
CEREBLON~DDB1 bound to cc-92480 with DDB1 in the linear conformation
Analyse CEREBLON~DDB1 bound to cc-92480 with DDB1 in the linear conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8D7U
- Type
- protein
- Length
- 1,516 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA damage-binding protein 1; Protein cereblon
- UniProt
- Q16531, Q96SW2
- Ligands
- QFC, ZN
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA damage-binding protein 1 | protein | 1132 | 5% helix, 46% strand | Q16531 |
| B | Protein cereblon | protein | 384 | 22% helix, 24% strand | Q96SW2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 848 | 0.86 | 0.88 | 76 | empty |
| 2 | 894 | 0.83 | 0.85 | 94 | empty |
| 3 | 978 | 0.80 | 0.82 | 124 | empty |
| 4 | 928 | 0.75 | 0.79 | 88 | empty |
| 5 | 520 | 0.72 | 0.81 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 2328 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 8D7U · Cereblon~DDB1 bound to CC-92480 with DDB1 in the linear conformation · the same entry in another collection · chain A against A, TM-score 1.00
- Q96SW2 · AlphaFold monomer V2.0 prediction for protein cereblon (Q96SW2) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q16531 · AlphaFold monomer V2.0 prediction for DNA damage-binding protein 1 (Q16531) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16531
- Every structure of UniProt Q96SW2
- Elsewhere: RCSB PDB 8D7U · PDBe 8D7U · UniProt Q16531 · UniProt Q96SW2
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