Ligand · QFC
QFC · Mezigdomide
QFC, Mezigdomide (C32 H30 F N5 O4, 567.6 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.
- Component
- QFC
- Formula
- C32 H30 F N5 O4
- Class
- ligand
- Structures
- 8
- PDB entries
- 5
Binding sites
QFC in 8 structures; the first of them:
- 8D7U · Cereblon~DDB1 bound to CC-92480 with DDB1 in the linear conformation · QFC B502 · binds PHE102, HIS103, PHE150, ILE152, ILE154, VAL350, ASN351, PRO352 and 8 more
- 8D7W · Cereblon~DDB1 bound to CC-92480 with DDB1 in the hinged conformation · QFC B502 · binds PHE102, PHE150, ILE152, ILE154, VAL350, ASN351, PRO352, HIS353 and 7 more
- 8D7Z · Cereblon-DDB1 bound to CC-92480 and Ikaros ZF1-2-3 · QFC B502 · binds PHE102, ILE152, VAL350, ASN351, PRO352, HIS353, HIS357, GLU377 and 10 more
- 8RQC · Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2 · QFC A602 · binds PHE102, ASP149, ILE152, ILE154, ASN351, PRO352, HIS353, GLU377 and 13 more
- 8D7U · CEREBLON~DDB1 bound to cc-92480 with DDB1 in the linear conformation · QFC B502 · binds PHE102, PHE150, ILE152, ILE154, VAL350, ASN351, PRO352, HIS353 and 6 more
- 8D7V · CEREBLON~DDB1 bound to cc-92480 with DDB1 in the twisted conformation · QFC B502 · binds PHE102, PHE150, ILE152, ILE154, ASN351, PRO352, HIS353, HIS378 and 5 more
- 8D7W · CEREBLON~DDB1 bound to cc-92480 with DDB1 in the hinged conformation · QFC B502 · binds PHE102, PHE150, ILE152, ASN351, PRO352, HIS353, HIS378, SER379 and 4 more
- 8D7Z · Cereblon-DDB1 bound to cc-92480 and ikaros ZF1-2-3 · QFC B502 · binds ILE152, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 7 more
Residues it binds most
TRP 9, PHE 9, HIS 9, ILE 9, ASN 9, PRO 9, SER 9, CYS 4, GLN 4, GLU 5 (residue and the binding sites it lines).
Found with
- ZN · Zinc ion
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