Research workbench
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate
Analyse Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XR4
- Type
- protein
- Length
- 1,275 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Excitatory amino acid transporter 2
- UniProt
- P43004
- Ligands
- PC1, GLU, Y01
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 78% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Excitatory amino acid transporter 2 | protein | 425 | 78% helix, 4% strand | P43004 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 24 copies · chains A, B, C
- GLU · Glutamic acid · ligand · 3 copies · chains A, B, C
- Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.88 | 0.88 | 50 | empty |
| 2 | 875 | 0.77 | 0.80 | 79 | PC1 |
| 3 | 835 | 0.77 | 0.80 | 80 | PC1 |
| 4 | 865 | 0.77 | 0.80 | 82 | PC1 |
| 5 | 454 | 0.64 | 0.78 | 49 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1428 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1414 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 1413 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7XR4 · Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate · the same entry in another collection · chain A against A, TM-score 1.00
- P43004 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 2 (P43004) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43004
- Elsewhere: RCSB PDB 7XR4 · PDBe 7XR4 · UniProt P43004
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