Research workbench
Crystal structure of chromobacterium violaceum effector copc in complex with host calmodulin and caspase-7
Analyse Crystal structure of chromobacterium violaceum effector copc in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WZS
- Type
- protein
- Length
- 704 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copc; Caspase-7; Calmodulin-1
- EC
- 3.4.22.60
- UniProt
- Q7NWF2, P55210, P0DP23
- Pockets
- 7 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Copc | protein | 434 | 44% helix, 12% strand | Q7NWF2 |
| B | Caspase-7 (EC 3.4.22.60) | protein | 206 | 32% helix, 26% strand | P55210 |
| C | Calmodulin-1 | protein | 64 | 52% helix, 6% strand | P0DP23 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 618 | 0.65 | 0.75 | 59 | empty |
| 2 | 81 | 0.50 | 0.83 | 16 | empty |
| 3 | 150 | 0.50 | 0.79 | 27 | empty |
| 4 | 89 | 0.46 | 0.81 | 15 | empty |
| 5 | 84 | 0.38 | 0.78 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1250 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 876 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7WZS · Crystal structure of Chromobacterium violaceum effector CopC in complex with host… · the same entry in another collection · chain A against A, TM-score 1.00
- P55210 · AlphaFold monomer V2.0 prediction for caspase-7 (P55210) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain C against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NWF2
- Every structure of UniProt P55210
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 7WZS · PDBe 7WZS · UniProt Q7NWF2 · UniProt P55210 · UniProt P0DP23
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