UniProt P55210
Caspase-7 large subunit (P55210)
Caspase-7 large subunit (UniProt P55210), EC 3.4.22.60: 85 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P55210
- Protein
- Caspase-7 large subunit
- EC
- 3.4.22.60
- Experimental structures
- 85
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 2 records with a druggable one
Structures
86 records of P55210 in the MolNFT archive: 85 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F1J | Crystal structure of caspase-7 in complex with acetyl-asp-glu-val-asp-cho | x-ray diffraction | A, B | — | — |
| 1F1J | Crystal structure of caspase-7 in complex with acetyl-asp-glu-val-asp- cho | x-ray diffraction | A, B | — | — |
| 1GQF | Crystal structure of human procaspase-7 | x-ray diffraction | A, B | — | — |
| 1GQF | Crystal structure of human procaspase-7 | x-ray diffraction | A, B | — | — |
| 1I4O | Crystal structure of the XIAP/CASPASE-7 complex | x-ray diffraction | A, B | — | — |
| 1I4O | Crystal structure of the XIAP/CASPASE-7 complex | x-ray diffraction | A, B | — | — |
| 1I51 | Crystal structure of caspase-7 complexed with xiap | x-ray diffraction | A, B, C, D | — | — |
| 1I51 | Crystal structure of caspase-7 complexed with xiap | x-ray diffraction | A, B, C, D | — | — |
| 1K86 | Crystal structure of caspase-7 | x-ray diffraction | A, B | — | — |
| 1K86 | Crystal structure of caspase-7 | x-ray diffraction | A, B | — | — |
| 1K88 | Crystal structure of procaspase-7 | x-ray diffraction | A, B | — | — |
| 1K88 | Crystal structure of procaspase-7 | x-ray diffraction | A, B | — | — |
| 1KMC | Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex | x-ray diffraction | A, B | — | — |
| 1KMC | Crystal structure of the caspase-7 / xiap-BIR2 complex | x-ray diffraction | A, B | — | — |
| 1SHJ | Caspase-7 in complex with DICA allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 1SHJ | Caspase-7 in complex with dica allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 1SHL | Caspase-7 in complex with fica allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 1SHL | Caspase-7 in complex with fica allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 2QL5 | Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QL5 | Crystal structure of caspase-7 with inhibitor ac-dmqd-cho | x-ray diffraction | A, B, C, D | — | — |
| 2QL7 | Crystal Structure of Caspase-7 with inhibitor AC-IEPD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QL7 | Crystal structure of caspase-7 with inhibitor ac-iepd-cho | x-ray diffraction | A, B, C, D | — | — |
| 2QL9 | Crystal Structure of Caspase-7 with inhibitor AC-DQMD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QL9 | Crystal structure of caspase-7 with inhibitor ac-dqmd-cho | x-ray diffraction | A, B, C, D | — | — |
| 2QLB | Crystal Structure of caspase-7 with inhibitor AC-ESMD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QLB | Crystal structure of caspase-7 with inhibitor ac-esmd-cho | x-ray diffraction | A, B, C, D | — | — |
| 2QLF | Crystal Structure of Caspase-7 with inhibitor AC-DNLD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QLF | Crystal structure of caspase-7 with inhibitor ac-dnld-cho | x-ray diffraction | A, B, C, D | — | — |
| 2QLJ | Crystal Structure of Caspase-7 with Inhibitor AC-WEHD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 2QLJ | Crystal structure of caspase-7 with inhibitor ac-wehd-cho | x-ray diffraction | A, B, C, D | — | — |
| 3EDR | The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 3EDR | The crystal structure of caspase-7 in complex with acetyl-ldesd-cho | x-ray diffraction | A, B, C, D | — | — |
| 3H1P | Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site | x-ray diffraction | A, B | — | — |
| 3H1P | Mature caspase-7 I213A with devd-cho inhibitor bound to active site | x-ray diffraction | A, B | — | — |
| 3IBC | Crystal Structure of Caspase-7 incomplex with Acetyl-YVAD-CHO | x-ray diffraction | A, B, C, D | — | — |
| 3IBC | Crystal structure of caspase-7 incomplex with acetyl-yvad- cho | x-ray diffraction | A, B, C, D | — | — |
| 3IBF | Crystal structure of unliganded caspase-7 | x-ray diffraction | A, B, C, D | — | — |
| 3IBF | Crystal structure of unliganded caspase-7 | x-ray diffraction | A, B, C, D | — | — |
| 3R5K | A designed redox-controlled caspase-7 | x-ray diffraction | A, B | — | — |
| 3R5K | A designed redox-controlled caspase-7 | x-ray diffraction | A, B | — | — |
| 4FDL | Crystal structure of Caspase-7 | x-ray diffraction | A, B | — | — |
| 4FDL | Crystal structure of caspase-7 | x-ray diffraction | A, B | — | — |
| 4FEA | Crystal structure of CASPASE-7 in Complex with allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 4FEA | Crystal structure of caspase-7 in complex with allosteric inhibitor | x-ray diffraction | A, B | — | — |
| 4HQ0 | Crystal Structure of mutant form of Caspase-7 | x-ray diffraction | A, B | — | — |
| 4HQ0 | Crystal structure of mutant form of caspase-7 | x-ray diffraction | A, B | — | — |
| 4HQR | Crystal Structure of mutant form of Caspase-7 | x-ray diffraction | A, B | — | — |
| 4HQR | Crystal structure of mutant form of caspase-7 | x-ray diffraction | A, B | — | — |
| 4JB8 | Caspase-7 in Complex with DARPin C7_16 | x-ray diffraction | A, B | — | — |
| 4JB8 | Caspase-7 in complex with darpin C7_16 | x-ray diffraction | A, B | — | — |
| 4JJ8 | Caspase-3 specific unnatural amino acid peptides | x-ray diffraction | A, B | — | — |
| 4JJ8 | Caspase-3 specific unnatural amino acid peptides | x-ray diffraction | A, B | — | — |
| 4JR1 | Human procaspase-7 bound to Ac-DEVD-CMK | x-ray diffraction | A, B | — | — |
| 4JR1 | Human procaspase-7 bound to ac-devd-cmk | x-ray diffraction | A, B | — | — |
| 4JR2 | Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK | x-ray diffraction | A, B | — | — |
| 4JR2 | Human procaspase-7/CASPASE-7 heterodimer bound to ac-devd-cmk | x-ray diffraction | A, B | — | — |
| 4LSZ | Caspase-7 in Complex with DARPin D7.18 | x-ray diffraction | A, B, C, D | — | — |
| 4LSZ | Caspase-7 in complex with darpin D7.18 | x-ray diffraction | A, B, C, D | — | — |
| 4ZVO | Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D… | x-ray diffraction | A, B, C, D | — | — |
| 4ZVO | Caspase-7 variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D… | x-ray diffraction | A, B, C, D | — | — |
26 records more on the page itself.
Ligands
Experiment against prediction
- 1F1J chain B against the predicted model P55210: TM-score 0.99, RMSD 0.56 Å
- 1F1J chain B against the predicted model P55210: TM-score 0.99, RMSD 0.56 Å
- 1F1J chain A against the predicted model P55210: TM-score 0.99, RMSD 0.56 Å
- 1F1J chain A against the predicted model P55210: TM-score 0.99, RMSD 0.56 Å
- 4ZVQ chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
- 4ZVQ chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
- 4ZVP chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
- 4ZVP chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
- 4ZVR chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
- 4ZVR chain A against the predicted model P55210: TM-score 0.99, RMSD 0.49 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.