Research workbench
Cryo-EM structure of inactive MGLU3 bound to LY341495
Analyse Cryo-EM structure of inactive MGLU3 bound to LY341495 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WI8
- Type
- protein
- Length
- 1,446 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 3
- UniProt
- Q14832
- Ligands
- Z99, NAG
- Pockets
- 15 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 33% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Metabotropic glutamate receptor 3 | protein | 723 | 33% helix, 10% strand | Q14832 |
Ligands and binding sites
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1119 | 0.84 | 0.85 | 124 | empty |
| 2 | 1097 | 0.84 | 0.85 | 123 | empty |
| 3 | 100 | 0.74 | 0.95 | 30 | empty |
| 4 | 62 | 0.66 | 0.94 | 21 | empty |
| 5 | 54 | 0.63 | 0.93 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 518 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14832
- Elsewhere: RCSB PDB 7WI8 · PDBe 7WI8 · UniProt Q14832
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