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Cryo-EM structure of LY341495/NAM-bound MGLU3

Analyse Cryo-EM structure of LY341495/NAM-bound MGLU3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7WI6
Type: protein
Length: 1,446 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 3
UniProt: Q14832
Ligands: Z99, NAG
Pockets: 16 · best druggability 0.86

Structure

electron microscopy · 1 distinct chain · 24% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Metabotropic glutamate receptor 3	protein	723	24% helix, 11% strand	Q14832

Ligands and binding sites

Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · ligand · 2 copies · chains A, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	939	0.86	0.87	108	empty
2	882	0.85	0.87	93	empty
3	62	0.65	0.93	24	empty
4	56	0.65	0.94	24	empty
5	53	0.63	0.93	21	empty

Interfaces

1 interface between chains.

A–B · 495 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

7WI6 · Cryo-EM structure of LY341495/NAM-bound mGlu3 · the same entry in another collection · chain A against A, TM-score 1.00
Q14832 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 3 (Q14832) · a predicted model of the same protein · chain B against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14832
Elsewhere: RCSB PDB 7WI6 · PDBe 7WI6 · UniProt Q14832

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