Crystal structure of serotonin 2A receptor in complex with non- hallucinogenic psychedelic analog

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• CLR · Cholesterol · ligand · 3 copies · chains A
• 93F · (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10, 15}]hexadeca-5(16),6,8-triene · ligand · chains A
• MG · Magnesium ion · metal · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 6 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
• 1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7WC9 · Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic… · the same entry in another collection · chain A against A, TM-score 1.00
• P28223 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2A (P28223) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P28223
• Elsewhere: RCSB PDB 7WC9 · PDBe 7WC9 · UniProt P28223