UniProt P28223
5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 (P28223)
5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 (UniProt P28223): 23 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P28223
- Protein
- 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 55 · 7 records with a druggable one
Structures
24 records of P28223 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6A93 | Crystal structure of 5-HT2AR in complex with risperidone | x-ray diffraction | A, B | 8NU, CLR, ZN, PLM | — |
| 6A93 | Crystal structure of 5-HT2AR in complex with risperidone | x-ray diffraction | A, B | 8NU, CLR, ZN, PLM | — |
| 6A94 | Crystal structure of 5-HT2AR in complex with zotepine | x-ray diffraction | A, B | ZOT, CLR, ZN, PLM, A6L | 8 (best 0.81) |
| 6A94 | Crystal structure of 5-HT2AR in complex with zotepine | x-ray diffraction | A, B | ZOT, CLR, ZN, PLM, A6L | — |
| 6WGT | Crystal structure of HTR2A with hallucinogenic agonist | x-ray diffraction | A, B, C | 7LD, CLR, OLA, PO4 | 15 (best 0.81) |
| 6WGT | Crystal structure of HTR2A with hallucinogenic agonist | x-ray diffraction | A, B, C | 7LD, CLR, OLA, PO4 | — |
| 6WH4 | Crystal structure of HTR2A with inverse agonist | x-ray diffraction | A, B, C | 89F, OLA, CLR, NDS | 15 (best 0.82) |
| 6WH4 | Crystal structure of HTR2A with inverse agonist | x-ray diffraction | A, B, C | 89F, OLA, CLR, NDS | — |
| 6WHA | HTR2A bound to 25-cn-nboh in complex with a mini-galpha-Q protein, BETA/GAMMA subunits and an… | electron microscopy | A | U0G | — |
| 7RAN | 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing… | electron microscopy | A | 3IQ | 5 (best 0.76) |
| 7RAN | 5-HT2AR bound to a novel agonist in complex with a mini-gq protein and an active-state stabilizing… | electron microscopy | A | 3IQ | — |
| 7VOD | Crystal structure of 5-HT2AR in complex with cariprazine | x-ray diffraction | A | MG, CLR, 7RU | — |
| 7VOE | Crystal structure of 5-HT2AR in complex with aripiprazole | x-ray diffraction | A | CLR, 9SC, MG | 3 (best 0.81) |
| 7VOE | Crystal structure of 5-HT2AR in complex with aripiprazole | x-ray diffraction | A | CLR, 9SC, MG | — |
| 7WC4 | Crystal structure of serotonin 2A receptor in complex with serotonin | x-ray diffraction | A | CLR, MG, SRO | — |
| 7WC5 | Crystal structure of serotonin 2A receptor in complex with psilocin | x-ray diffraction | A | MG, CLR, 91Q | — |
| 7WC6 | Crystal structure of serotonin 2A receptor in complex with LSD | x-ray diffraction | A | MG, CLR, 7LD | — |
| 7WC6 | Crystal structure of serotonin 2A receptor in complex with lsd | x-ray diffraction | A | MG, CLR, 7LD | — |
| 7WC7 | Crystal structure of serotonin 2A receptor in complex with lisuride | x-ray diffraction | A | MG, CLR, H8G | — |
| 7WC8 | Crystal structure of serotonin 2A receptor in complex with lumateperone | x-ray diffraction | A | MG, CLR, 92S | — |
| 7WC9 | Crystal structure of serotonin 2A receptor in complex with non- hallucinogenic psychedelic analog | x-ray diffraction | A | MG, CLR, 93F | — |
| 8JT8 | Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 | x-ray diffraction | A | MG, EZX, CLR | 4 (best 0.80) |
| 8ZMG | Crystal structure of an inverse agonist antipsychotic drug pimavanserin-bound 5-HT2A | x-ray diffraction | A, B | A1L11 | 5 (best 0.80) |
| P28223 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2A (P28223) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 19 records
- MG · Magnesium ion · in 11 records
- 7LD · (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide · in 4 records
- OLA · Oleic acid · in 4 records
- PLM · Palmitic acid · in 4 records
- ZN · Zinc ion · in 4 records
- 3IQ · (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3, 6-tetrahydropyridin-1-ium · in 2 records
- 89F · 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine · in 2 records
- 8NU · 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one · in 2 records
- 9SC · 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one · in 2 records
- A6L · 2,3-dihydroxypropyl (9Z)-octadec-9-enoate · in 2 records
- NDS · Ethyl dimethyl ammonio propane sulfonate · in 2 records
- PO4 · Phosphate ion · in 2 records
- ZOT · 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine · in 2 records
- 7RU · 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea · in 1 record
- 91Q · 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol · in 1 record
- 92S · 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5, 7,9(16)-trien-12-yl]butan-1-one · in 1 record
- 93F · (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10, 15}]hexadeca-5(16),6,8-triene · in 1 record
- A1L11 · Pimavanserin · in 1 record
- EZX · 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one · in 1 record
- H8G · N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea · in 1 record
- SRO · Serotonin · in 1 record
- U0G · 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile · in 1 record
Experiment against prediction
- 6WHA chain A against the predicted model P28223: TM-score 0.91, RMSD 2.05 Å
- 7RAN chain A against the predicted model P28223: TM-score 0.91, RMSD 2.17 Å
- 7RAN chain A against the predicted model P28223: TM-score 0.91, RMSD 2.17 Å
- 7WC6 chain A against the predicted model P28223: TM-score 0.86, RMSD 1.76 Å
- 7WC6 chain A against the predicted model P28223: TM-score 0.86, RMSD 1.76 Å
- 6A94 chain B against the predicted model P28223: TM-score 0.86, RMSD 1.74 Å
- 6A94 chain B against the predicted model P28223: TM-score 0.86, RMSD 1.74 Å
- 7VOD chain A against the predicted model P28223: TM-score 0.86, RMSD 1.87 Å
- 6A93 chain B against the predicted model P28223: TM-score 0.86, RMSD 1.79 Å
- 6A93 chain B against the predicted model P28223: TM-score 0.86, RMSD 1.79 Å
Elsewhere
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