Research workbench
Crystal structure of human thyroid hormone receptor beta lbd in complex with specific agonist gc-24
Analyse Crystal structure of human thyroid hormone receptor beta lbd in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q4X
- Type
- protein
- Length
- 239 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thyroid hormone receptor beta-1
- UniProt
- P10828
- Ligands
- G24
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroid hormone receptor beta-1 | protein | 239 | 65% helix, 4% strand | P10828 |
Ligands and binding sites
- G24 · [4-(3-benzyl-4-hydroxybenzyl)-3,5-dimethylphenoxy]acetic acid · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.80 | 0.91 | 42 | G24 |
| 2 | 139 | 0.44 | 0.76 | 19 | empty |
| 3 | 89 | 0.42 | 0.79 | 18 | empty |
Compared structures
- 1Q4X · Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific… · the same entry in another collection · chain A against A, TM-score 1.00
- P10828 · AlphaFold monomer V2.0 prediction for thyroid hormone receptor beta (P10828) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10828
- Elsewhere: RCSB PDB 1Q4X · PDBe 1Q4X · UniProt P10828
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