Research workbench

Biogenesis module of human telomerase holoenzyme

Analyse Biogenesis module of human telomerase holoenzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7V9A
Type: protein + RNA
Length: 1,869 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Telomerase cajal body protein 1; H/ACA ribonucleoprotein complex subunit DKC1; H/ACA…
EC: 5.4.99.-
UniProt: Q9BUR4, O60832, Q9NY12, Q9NX24, Q9NPE3
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 10 distinct chains · 20% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Telomerase cajal body protein 1	protein	377	3% helix, 38% strand	Q9BUR4
C	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-)	protein	393	25% helix, 25% strand	O60832
D	H/ACA ribonucleoprotein complex subunit 1	protein	117	0% helix, 39% strand	Q9NY12
E	H/ACA ribonucleoprotein complex subunit 2	protein	129	46% helix, 11% strand	Q9NX24
F	H/ACA ribonucleoprotein complex subunit 3	protein	62	18% helix, 19% strand	Q9NPE3
G	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-)	protein	349	26% helix, 26% strand	O60832
H	H/ACA ribonucleoprotein complex subunit 1	protein	98	3% helix, 40% strand	Q9NY12
I	H/ACA ribonucleoprotein complex subunit 2	protein	134	44% helix, 10% strand	Q9NX24
J	H/ACA ribonucleoprotein complex subunit 3	protein	64	16% helix, 19% strand	Q9NPE3
R	Telomerase RNA component	rna	146	—	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	857	0.82	0.85	76	empty
2	795	0.82	0.85	61	empty
3	670	0.75	0.81	42	empty
4	1040	0.74	0.77	89	empty
5	630	0.73	0.80	46	empty

Interfaces

23 interfaces between chains.

G–R · 2405 Å² buried · 24 hydrogen bonds · protein-nucleic
G–J · 1741 Å² buried · 10 hydrogen bonds · protein-protein
C–F · 1699 Å² buried · 5 hydrogen bonds · protein-protein
C–R · 1689 Å² buried · 18 hydrogen bonds · protein-nucleic
C–G · 1635 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7V9A · biogenesis module of human telomerase holoenzyme · the same entry in another collection · chain R against R, TM-score 1.00
O60832 · AlphaFold monomer V2.0 prediction for H/ACA ribonucleoprotein complex subunit DKC1… · a predicted model of the same protein · chain G against A, TM-score 0.93
Q9NX24 · AlphaFold monomer V2.0 prediction for H/ACA ribonucleoprotein complex subunit 2 (Q9NX24) · a predicted model of the same protein · chain E against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BUR4
Every structure of UniProt O60832
Every structure of UniProt Q9NY12
Every structure of UniProt Q9NX24
Every structure of UniProt Q9NPE3
Elsewhere: RCSB PDB 7V9A · PDBe 7V9A · UniProt Q9BUR4 · UniProt O60832 · UniProt Q9NY12 · UniProt Q9NX24 · UniProt Q9NPE3

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