Research workbench
Crystal structure of the heterodimeric hif-3A:ARNT complex
Analyse Crystal structure of the heterodimeric hif-3A:ARNT complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V7L
- Type
- protein
- Length
- 579 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aryl hydrocarbon receptor nuclear translocator; Hypoxia-inducible factor 3-alpha
- UniProt
- P53762, Q0VBL6
- Pockets
- 10 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aryl hydrocarbon receptor nuclear translocator | protein | 280 | 33% helix, 32% strand | P53762 |
| B | Hypoxia-inducible factor 3-alpha | protein | 299 | 36% helix, 29% strand | Q0VBL6 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.72 | 0.98 | 23 | empty |
| 2 | 465 | 0.67 | 0.79 | 50 | empty |
| 3 | 206 | 0.56 | 0.79 | 27 | empty |
| 4 | 190 | 0.53 | 0.78 | 24 | empty |
| 5 | 161 | 0.52 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 4387 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7V7L · Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q0VBL6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 3-alpha (Q0VBL6) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P53762 · AlphaFold monomer V2.0 prediction for aryl hydrocarbon receptor nuclear translocator… · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53762
- Every structure of UniProt Q0VBL6
- Elsewhere: RCSB PDB 7V7L · PDBe 7V7L · UniProt P53762 · UniProt Q0VBL6
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