Research workbench

Integrin ALPHAM/BETA2 ectodomain

Analyse Integrin ALPHAM/BETA2 ectodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7USM
Type: protein
Length: 1,521 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin alpha-M; Integrin beta
UniProt: P11215, A0A494C0X7
Ligands: NAG, CA
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 2 distinct chains · 11% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin alpha-M	protein	848	4% helix, 48% strand	P11215
B	Integrin beta	protein	673	21% helix, 28% strand	A0A494C0X7

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B
CA · Calcium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1188	0.82	0.83	91	empty
2	707	0.74	0.80	55	empty
3	387	0.63	0.78	47	empty
4	244	0.56	0.78	31	empty
5	302	0.55	0.76	31	empty

Interfaces

1 interface between chains.

A–B · 2756 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 disulfide, 10 glycan (disulfide, N-glycosylation).

Compared structures

7USM · Integrin alphaM/beta2 ectodomain · the same entry in another collection · chain A against A, TM-score 1.00
P11215 · AlphaFold monomer V2.0 prediction for integrin alpha-M (P11215) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11215
Every structure of UniProt A0A494C0X7
Elsewhere: RCSB PDB 7USM · PDBe 7USM · UniProt P11215 · UniProt A0A494C0X7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.