UniProt P11215
Integrin alpha-M (P11215)
Integrin alpha-M (UniProt P11215): 38 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P11215
- Protein
- Integrin alpha-M
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 8 · 2 records with a druggable one
Structures
39 records of P11215 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BHO | Mac-1 I domain magnesium complex | x-ray diffraction | 1, 2 | — | — |
| 1BHO | Mac-1 I domain magnesium complex | x-ray diffraction | 1, 2 | — | — |
| 1BHQ | Mac-1 I domain cadmium complex | x-ray diffraction | 1, 2 | — | — |
| 1BHQ | Mac-1 I domain cadmium complex | x-ray diffraction | 1, 2 | — | — |
| 1IDN | Mac-1 I domain metal free | x-ray diffraction | 1, 2 | — | — |
| 1IDN | Mac-1 I domain metal free | x-ray diffraction | 1, 2 | — | — |
| 1IDO | I-domain from integrin CR3, MG2+ bound | x-ray diffraction | A | — | — |
| 1IDO | I-domain from integrin CR3, MG2+ bound | x-ray diffraction | A | — | — |
| 1JLM | I-domain from integrin CR3, MN2+ bound | x-ray diffraction | A | — | — |
| 1JLM | I-domain from integrin CR3, MN2+ bound | x-ray diffraction | A | — | — |
| 1M1U | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11B… | x-ray diffraction | A | — | — |
| 1M1U | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11B… | x-ray diffraction | A | — | — |
| 1MF7 | Integrin alpha M I domain | x-ray diffraction | A | — | — |
| 1MF7 | Integrin alpha M I domain | x-ray diffraction | A | — | — |
| 1N9Z | Integrin alpha M I domain mutant | x-ray diffraction | A | — | — |
| 1N9Z | Integrin alpha M I domain mutant | x-ray diffraction | A | — | — |
| 1NA5 | Integrin alpha M I domain | x-ray diffraction | A | — | — |
| 1NA5 | Integrin alpha M I domain | x-ray diffraction | A | — | — |
| 2LKE | Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails | solution nmr | A | — | — |
| 2LKE | Structures and interaction analyses of the integrin alpha-M beta-2 cytoplasmic tails | solution nmr | A | — | — |
| 2LKJ | Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails | solution nmr | A | — | — |
| 2LKJ | Structures and interaction analyses of the integrin alpha-M beta-2 cytoplasmic tails | solution nmr | A | — | — |
| 3Q3G | Crystal Structure of A-domain in complex with antibody | x-ray diffraction | G, E, I, L | — | — |
| 3Q3G | Crystal structure of a-domain in complex with antibody | x-ray diffraction | G, E, I, L | — | — |
| 3QA3 | Crystal Structure of A-domain in complex with antibody | x-ray diffraction | G, E, I, L | — | — |
| 3QA3 | Crystal structure of a-domain in complex with antibody | x-ray diffraction | G, E, I, L | — | — |
| 4M76 | Integrin I domain of complement receptor 3 in complex with C3d | x-ray diffraction | B | — | — |
| 4M76 | Integrin I domain of complement receptor 3 in complex with C3D | x-ray diffraction | B | — | — |
| 4XW2 | Structural basis for simvastatin competitive antagonism of complement receptor 3 | x-ray diffraction | A | — | — |
| 4XW2 | Structural basis for simvastatin competitive antagonism of complement receptor 3 | x-ray diffraction | A | — | — |
| 6RHW | Crystal structure of human CD11B I-domain (CD11B-I) in complex with staphylococcus aureus octameric… | x-ray diffraction | C | MG | — |
| 7AKK | Structure of a complement factor-receptor complex | x-ray diffraction | D, H | MG | — |
| 7P2D | Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody | x-ray diffraction | A | NAG, CA | 6 (best 0.83) |
| 7P2D | Structure of ALPHAMBETA2/CD11BCD18 headpiece in complex with a nanobody | x-ray diffraction | A | NAG, CA | — |
| 7USL | Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab | electron microscopy | A | NAG, FUC, CA | — |
| 7USL | Integrin ALPHAM/BETA2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab | electron microscopy | A | NAG, FUC, CA | — |
| 7USM | Integrin ALPHAM/BETA2 ectodomain | electron microscopy | A | NAG, CA | — |
| 8VOH | HADDOCK models of human alphaM I-domain bound to the the N-terminal domain of the cytokine… | solution nmr | A | — | 2 (best 0.52) |
| P11215 | AlphaFold monomer V2.0 prediction for integrin alpha-M (P11215) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1JLM chain A against the predicted model P11215: TM-score 0.99, RMSD 0.47 Å
- 1JLM chain A against the predicted model P11215: TM-score 0.99, RMSD 0.47 Å
- 3Q3G chain G against the predicted model P11215: TM-score 0.99, RMSD 0.50 Å
- 3Q3G chain G against the predicted model P11215: TM-score 0.99, RMSD 0.50 Å
- 1BHQ chain 1 against the predicted model P11215: TM-score 0.99, RMSD 0.58 Å
- 1BHQ chain 1 against the predicted model P11215: TM-score 0.99, RMSD 0.58 Å
- 1BHO chain 1 against the predicted model P11215: TM-score 0.99, RMSD 0.59 Å
- 1BHO chain 1 against the predicted model P11215: TM-score 0.99, RMSD 0.59 Å
- 3QA3 chain G against the predicted model P11215: TM-score 0.99, RMSD 0.60 Å
- 3QA3 chain G against the predicted model P11215: TM-score 0.99, RMSD 0.60 Å
Elsewhere
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