Research workbench
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with KIR6.2-ctd in the up conformation
Analyse Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TYS
- Type
- protein
- Length
- 2,794 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P70673, Q09427
- Ligands
- 65I, ATP, POV, BJX, NAG, K
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 363 | — | P70673 |
| B | — | protein | 334 | — | P70673 |
| C | — | protein | 333 | — | P70673 |
| D | — | protein | 332 | — | P70673 |
| E | — | protein | 1432 | — | Q09427 |
Ligands and binding sites
- 65I · (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate · ligand · 6 copies · chains A, E
- ATP · Adenosine-5'-triphosphate · ligand · 5 copies · chains A, D, B, C, E
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 5 copies · chains A, E, B, C, D
- BJX · Repaglinide · ligand · chains A, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains E
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7TYS · Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and… · the same entry in another collection · chain E against E, TM-score 1.00
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain C against A, TM-score 0.98
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70673
- Every structure of UniProt Q09427
- Elsewhere: RCSB PDB 7TYS · PDBe 7TYS · UniProt P70673 · UniProt Q09427
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