Research workbench
Human telomerase catalytic core rnp with H2A/H2B
Analyse Human telomerase catalytic core rnp with H2A/H2B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TRF
- Type
- protein + DNA + RNA
- Length
- 1,330 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H2B type 1-C/E/F/G/I; Histone H2A; Telomerase RNA, partial sequence; Telomerase…
- EC
- 2.7.7.49
- UniProt
- P62807, A0A024RAS2, O14746
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 5 distinct chains · 51% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Histone H2B type 1-C/E/F/G/I | protein | 90 | 77% helix, 3% strand | P62807 |
| E | Histone H2A | protein | 82 | 67% helix, 4% strand | A0A024RAS2 |
| B | Telomerase RNA, partial sequence | rna | 217 | — | — |
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 934 | 47% helix, 16% strand | O14746 |
| D | Telomeric repeat substrate | dna | 7 | — | — |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1158 | 0.86 | 0.87 | 94 | empty |
| 2 | 1085 | 0.79 | 0.81 | 72 | empty |
| 3 | 855 | 0.77 | 0.81 | 48 | empty |
| 4 | 1079 | 0.74 | 0.77 | 63 | empty |
| 5 | 118 | 0.72 | 0.92 | 30 | empty |
Interfaces
6 interfaces between chains.
- B–A · 6163 Ų buried · 104 hydrogen bonds · protein-nucleic
- F–E · 2475 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 755 Ų buried · 10 hydrogen bonds · protein-nucleic
- F–B · 482 Ų buried · 6 hydrogen bonds · protein-nucleic
- E–B · 411 Ų buried · 4 hydrogen bonds · protein-nucleic
Compared structures
- 7TRF · Human telomerase catalytic core RNP with H2A/H2B · the same entry in another collection · chain E against E, TM-score 1.00
- O14746 · AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P62807 · AlphaFold monomer V2.0 prediction for histone H2B type 1-C/E/F/G/I (P62807) · a predicted model of the same protein · chain F against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62807
- Every structure of UniProt A0A024RAS2
- Every structure of UniProt O14746
- Elsewhere: RCSB PDB 7TRF · PDBe 7TRF · UniProt P62807 · UniProt A0A024RAS2 · UniProt O14746
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