Research workbench
Cryo-EM structure of the 20S alpha 3 deletion proteasome core particle in complex with FUB1
Analyse Cryo-EM structure of the 20S alpha 3 deletion proteasome core particle in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TEO
- Type
- protein
- Length
- 6,288 residues
- Chains
- 30
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit beta type-6; Proteasome subunit beta type-7; Proteasome subunit alpha…
- EC
- 3.4.25.1
- UniProt
- P23724, P30657, P21243, P23639, P40303, P32379, P40302, P21242, P38624, P25043, P25451, P22141, P30656, P25659
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 15 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, M | Proteasome subunit beta type-6 (EC 3.4.25.1) | protein | 221 | 29% helix, 33% strand | P23724 |
| 2, N | Proteasome subunit beta type-7 (EC 3.4.25.1) | protein | 230 | 32% helix, 32% strand | P30657 |
| A, O | Proteasome subunit alpha type-1 (EC 3.4.25.1) | protein | 234 | 40% helix, 25% strand | P21243 |
| B, P | Proteasome subunit alpha type-2 (EC 3.4.25.1) | protein | 241 | 38% helix, 25% strand | P23639 |
| C, Q | Proteasome subunit alpha type-4 (EC 3.4.25.1) | protein | 222 | 40% helix, 26% strand | P40303 |
| D, R | Proteasome subunit alpha type-4 (EC 3.4.25.1) | protein | 208 | 40% helix, 24% strand | P40303 |
| E, S | Proteasome subunit alpha type-5 (EC 3.4.25.1) | protein | 207 | 35% helix, 28% strand | P32379 |
| F, T | Proteasome subunit alpha type-6 (EC 3.4.25.1) | protein | 231 | 34% helix, 28% strand | P40302 |
| G, U | Proteasome subunit alpha type-7 (EC 3.4.25.1) | protein | 243 | 37% helix, 26% strand | P21242 |
| H, V | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 196 | 36% helix, 35% strand | P38624 |
| I, W | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 220 | 30% helix, 36% strand | P25043 |
| J, X | Proteasome subunit beta type-3 (EC 3.4.25.1) | protein | 203 | 33% helix, 31% strand | P25451 |
| K, Y | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 195 | 35% helix, 33% strand | P22141 |
| L, Z | Proteasome subunit beta type-5 (EC 3.4.25.1) | protein | 212 | 36% helix, 34% strand | P30656 |
| a, b | Silencing boundary-establishment protein FUB1 | protein | 81 | 17% helix, 2% strand | P25659 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1069 | 0.83 | 0.84 | 153 | empty |
| 2 | 1013 | 0.82 | 0.84 | 146 | empty |
| 3 | 896 | 0.81 | 0.83 | 99 | empty |
| 4 | 856 | 0.78 | 0.81 | 113 | empty |
| 5 | 781 | 0.78 | 0.82 | 79 | empty |
Interfaces
97 interfaces between chains.
- I–J · 1714 Ų buried · 24 hydrogen bonds · protein-protein
- W–X · 1705 Ų buried · 22 hydrogen bonds · protein-protein
- 1–I · 1455 Ų buried · 23 hydrogen bonds · protein-protein
- M–W · 1435 Ų buried · 22 hydrogen bonds · protein-protein
- T–U · 1378 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 7TEO · Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle in complex with… · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23724
- Every structure of UniProt P30657
- Every structure of UniProt P21243
- Every structure of UniProt P23639
- Every structure of UniProt P40303
- Every structure of UniProt P32379
- Every structure of UniProt P40302
- Every structure of UniProt P21242
- Every structure of UniProt P38624
- Every structure of UniProt P25043
- Every structure of UniProt P25451
- Every structure of UniProt P22141
- Every structure of UniProt P30656
- Every structure of UniProt P25659
- Elsewhere: RCSB PDB 7TEO · PDBe 7TEO · UniProt P23724 · UniProt P30657 · UniProt P21243 · UniProt P23639 · UniProt P40303 · UniProt P32379 · UniProt P40302 · UniProt P21242 · UniProt P38624 · UniProt P25043 · UniProt P25451 · UniProt P22141 · UniProt P30656 · UniProt P25659
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