Research workbench
Crystal structure of human SHOC2: a leucine-rich repeat protein
Analyse Crystal structure of human SHOC2: a leucine-rich repeat protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7T7A
- Type
- protein
- Length
- 986 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat protein shoc-2
- UniProt
- Q9UQ13
- Ligands
- MG, NO3
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat protein shoc-2 | protein | 494 | 22% helix, 12% strand | Q9UQ13 |
| B | Leucine-rich repeat protein shoc-2 | protein | 492 | 23% helix, 12% strand | Q9UQ13 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.76 | 0.96 | 24 | MG |
| 2 | 380 | 0.61 | 0.77 | 39 | NO3 |
| 3 | 238 | 0.45 | 0.72 | 26 | empty |
| 4 | 164 | 0.43 | 0.74 | 24 | empty |
| 5 | 101 | 0.35 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1222 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7T7A · Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UQ13 · AlphaFold monomer V2.0 prediction for leucine-rich repeat protein shoc-2 (Q9UQ13) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQ13
- Elsewhere: RCSB PDB 7T7A · PDBe 7T7A · UniProt Q9UQ13
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.