UniProt Q9UQ13
Leucine-rich repeat protein SHOC-2 (Q9UQ13)
Leucine-rich repeat protein SHOC-2 (UniProt Q9UQ13): 13 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UQ13
- Protein
- Leucine-rich repeat protein SHOC-2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 49 · 5 records with a druggable one
Structures
14 records of Q9UQ13 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7SD0 | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | electron microscopy | A | — | 6 (best 0.85) |
| 7SD0 | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | electron microscopy | A | — | — |
| 7SD1 | Crystal structure of SHOC2 | x-ray diffraction | A, B, C, D | — | 15 (best 0.84) |
| 7SD1 | Crystal structure of SHOC2 | x-ray diffraction | A, B, C, D | — | — |
| 7T7A | Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein | x-ray diffraction | A, B | MG, NO3 | 6 (best 0.76) |
| 7T7A | Crystal structure of human SHOC2: a leucine-rich repeat protein | x-ray diffraction | A, B | MG, NO3 | — |
| 7TVF | Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom | x-ray diffraction | A, D | SO4, CL | 14 (best 0.87) |
| 7TVF | Crystal structure of the SHOC2-mras-PP1CA (smp) complex to a resolution of 2.17 ångström | x-ray diffraction | A, D | SO4, CL | — |
| 7TVG | Crystal structure of SHOC2 to a resolution of 2.4 ångström | x-ray diffraction | D | SO4 | — |
| 7TXH | Human mras Q71R in complex with human SHOC2 lrr domain M173I and human PP1CA | x-ray diffraction | B, E | PO4 | — |
| 7TYG | Structure of the human leucine rich repeat protein SHOC2, residues 80- 582 | x-ray diffraction | A, B | MG | — |
| 7UPI | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | electron microscopy | C | — | 6 (best 0.86) |
| 7UPI | Cryo-EM structure of SHOC2-PP1C-mras holophosphatase complex | electron microscopy | C | — | — |
| Q9UQ13 | AlphaFold monomer V2.0 prediction for leucine-rich repeat protein shoc-2 (Q9UQ13) | predicted | A | — | 2 (best 0.48) |
Ligands
Experiment against prediction
- 7SD1 chain A against the predicted model Q9UQ13: TM-score 1.00, RMSD 0.42 Å
- 7SD1 chain A against the predicted model Q9UQ13: TM-score 1.00, RMSD 0.42 Å
- 7SD1 chain B against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.86 Å
- 7SD1 chain B against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.86 Å
- 7T7A chain B against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.78 Å
- 7T7A chain B against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.78 Å
- 7TYG chain A against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.79 Å
- 7SD1 chain D against the predicted model Q9UQ13: TM-score 0.99, RMSD 0.55 Å
- 7TYG chain B against the predicted model Q9UQ13: TM-score 0.98, RMSD 1.01 Å
- 7SD1 chain C against the predicted model Q9UQ13: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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