Research workbench
Full-length insulin receptor bound with unsaturated insulin wt (2 insulins bound) asymmetric conformation (conformation 1)
Analyse Full-length insulin receptor bound with unsaturated insulin wt (2 insulins… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7STJ
- Type
- protein
- Length
- 1,672 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 18 · best druggability 0.82
Structure
electron microscopy · 4 distinct chains · 12% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.10.1) | protein | 786 | 10% helix, 31% strand | P15208 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 797 | 10% helix, 29% strand | P15208 |
| C | Insulin | protein | 48 | 44% helix, 4% strand | P01308 |
| D | Insulin | protein | 41 | 49% helix, 0% strand | P01308 |
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 316 | 0.82 | 0.91 | 53 | empty |
| 2 | 267 | 0.81 | 0.92 | 41 | empty |
| 3 | 1191 | 0.80 | 0.82 | 123 | empty |
| 4 | 171 | 0.80 | 0.94 | 40 | empty |
| 5 | 117 | 0.79 | 0.96 | 28 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1851 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 790 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 733 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 457 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 425 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 37 disulfide (disulfide).
Compared structures
- 7STJ · Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound)… · the same entry in another collection · chain A against A, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7STJ · PDBe 7STJ · UniProt P15208 · UniProt P01308
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