Research workbench
Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric conformation
Analyse Full-length insulin receptor bound with unsaturated insulin wt (2 insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7STH
- Type
- protein
- Length
- 1,736 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 16 · best druggability 0.76
Structure
electron microscopy · 2 distinct chains · 13% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin receptor (EC 2.7.10.1) | protein | 820 | 12% helix, 30% strand | P15208 |
| C, D | Insulin | protein | 48 | 42% helix, 4% strand | P01308 |
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 731 | 0.76 | 0.81 | 73 | empty |
| 2 | 885 | 0.76 | 0.79 | 74 | empty |
| 3 | 321 | 0.74 | 0.86 | 46 | empty |
| 4 | 362 | 0.62 | 0.78 | 34 | empty |
| 5 | 362 | 0.60 | 0.77 | 36 | empty |
Interfaces
5 interfaces between chains.
- A–B · 3064 Ų buried · 26 hydrogen bonds · protein-protein
- A–D · 848 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 836 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 441 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 441 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 40 disulfide (disulfide).
Compared structures
- 7STH · Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound)… · the same entry in another collection · chain A against A, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7STH · PDBe 7STH · UniProt P15208 · UniProt P01308
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