Research workbench
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation
Analyse Full-length insulin receptor bound with site 2 binding deficient mutant insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SL6
- Type
- protein
- Length
- 1,734 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin B chain; Insulin a chain
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 3 distinct chains · 15% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin receptor (EC 2.7.10.1) | protein | 819 | 13% helix, 30% strand | P15208 |
| E, F | Insulin B chain | protein | 27 | 37% helix, 4% strand | P01308 |
| C, D | Insulin a chain | protein | 21 | 57% helix, 5% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 980 | 0.76 | 0.79 | 71 | empty |
| 2 | 927 | 0.76 | 0.79 | 81 | empty |
| 3 | 450 | 0.69 | 0.80 | 54 | empty |
| 4 | 302 | 0.62 | 0.79 | 38 | empty |
| 5 | 382 | 0.62 | 0.77 | 41 | empty |
Interfaces
11 interfaces between chains.
- A–B · 2798 Ų buried · 24 hydrogen bonds · protein-protein
- E–C · 670 Ų buried · 11 hydrogen bonds · protein-protein
- F–D · 664 Ų buried · 11 hydrogen bonds · protein-protein
- A–F · 524 Ų buried · 1 hydrogen bond · protein-protein
- B–E · 523 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 40 disulfide (disulfide).
Compared structures
- 7SL6 · Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)… · the same entry in another collection · chain E against E, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7SL6 · PDBe 7SL6 · UniProt P15208 · UniProt P01308
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