Research workbench
Leg region of a complex of igf-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Analyse Leg region of a complex of igf-I with the ectodomain of a hybrid insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7S8V
- Type
- protein
- Length
- 782 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 1 receptor; Insulin receptor
- EC
- 2.7.10.1
- UniProt
- P08069, P06213
- Ligands
- NAG, BMA
- Pockets
- 10 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 9% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 1 receptor (EC 2.7.10.1) | protein | 264 | 11% helix, 36% strand | P08069 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 518 | 8% helix, 35% strand | P06213 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 711 | 0.77 | 0.81 | 88 | empty |
| 2 | 691 | 0.68 | 0.76 | 71 | empty |
| 3 | 551 | 0.67 | 0.78 | 51 | empty |
| 4 | 218 | 0.58 | 0.80 | 34 | NAG |
| 5 | 173 | 0.49 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1789 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide, 8 glycan (disulfide, N-glycosylation).
Compared structures
- 7S8V · Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Every structure of UniProt P06213
- Elsewhere: RCSB PDB 7S8V · PDBe 7S8V · UniProt P08069 · UniProt P06213
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