Research workbench
Insulin degrading enzyme PC/PC
Analyse Insulin degrading enzyme PC/PC in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RZI
- Type
- protein
- Length
- 1,921 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine-free insulin-degrading enzyme; Insulin a chain; Insulin B chain
- EC
- 3.4.24.56
- UniProt
- P14735, P01308
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 948 | 39% helix, 18% strand | P14735 |
| B | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 938 | 39% helix, 19% strand | P14735 |
| a | Insulin a chain | protein | 11 | 0% helix, 18% strand | P01308 |
| b, d | Insulin B chain | protein | 5 | 0% helix, 0% strand | P01308 |
| c | Insulin a chain | protein | 14 | 0% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.84 | 0.85 | 106 | empty |
| 2 | 1154 | 0.83 | 0.84 | 120 | empty |
| 3 | 928 | 0.83 | 0.84 | 98 | empty |
| 4 | 1112 | 0.79 | 0.81 | 124 | empty |
| 5 | 517 | 0.70 | 0.80 | 64 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1251 Ų buried · 14 hydrogen bonds · protein-protein
- B–c · 908 Ų buried · 12 hydrogen bonds · protein-protein
- A–a · 756 Ų buried · 9 hydrogen bonds · protein-protein
- B–d · 430 Ų buried · 7 hydrogen bonds · protein-protein
- A–b · 364 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7RZI · Insulin Degrading Enzyme pC/pC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14735
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7RZI · PDBe 7RZI · UniProt P14735 · UniProt P01308
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