UniProt P14735
Insulin-degrading enzyme (P14735)
Insulin-degrading enzyme (UniProt P14735), EC 3.4.24.56: 97 experimental structures on GenesisL1, 6 ligands bound, 156 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P14735
- Protein
- Insulin-degrading enzyme
- EC
- 3.4.24.56
- Experimental structures
- 97
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 156 · 8 records with a druggable one
Structures
97 records of P14735 in the MolNFT archive: 97 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G47 | Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40) | x-ray diffraction | A, B | — | — |
| 2G47 | Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40) | x-ray diffraction | A, B | — | — |
| 2JG4 | Substrate-free IDE structure in its closed conformation | x-ray diffraction | A, B | — | — |
| 2JG4 | Substrate-free ide structure in its closed conformation | x-ray diffraction | A, B | — | — |
| 2WBY | Crystal structure of human insulin-degrading enzyme in complex with insulin | x-ray diffraction | A, B | — | — |
| 2WBY | Crystal structure of human insulin-degrading enzyme in complex with insulin | x-ray diffraction | A, B | — | — |
| 2WC0 | crystal structure of human insulin degrading enzyme in complex with iodinated insulin | x-ray diffraction | A, B | — | — |
| 2WC0 | Crystal structure of human insulin degrading enzyme in complex with iodinated insulin | x-ray diffraction | A, B | — | — |
| 2WK3 | Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) | x-ray diffraction | A, B | — | — |
| 2WK3 | Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) | x-ray diffraction | A, B | — | — |
| 2YPU | human insulin degrading enzyme E111Q in complex with inhibitor compound 41367 | x-ray diffraction | A, B | — | — |
| 2YPU | Human insulin degrading enzyme E111Q in complex with inhibitor compound 41367 | x-ray diffraction | A, B | — | — |
| 3CWW | Crystal Structure of IDE-bradykinin complex | x-ray diffraction | A, B | — | — |
| 3CWW | Crystal structure of ide-bradykinin complex | x-ray diffraction | A, B | — | — |
| 3E4A | Human IDE-inhibitor complex at 2.6 angstrom resolution | x-ray diffraction | A, B | — | — |
| 3E4A | Human ide-inhibitor complex at 2.6 ångström resolution | x-ray diffraction | A, B | — | — |
| 3E50 | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | x-ray diffraction | A, B | — | — |
| 3E50 | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | x-ray diffraction | A, B | — | — |
| 3H44 | Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1… | x-ray diffraction | A, B | — | — |
| 3H44 | Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1… | x-ray diffraction | A, B | — | — |
| 3HGZ | Crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | A, B | — | — |
| 3HGZ | Crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | A, B | — | — |
| 3N56 | Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic… | x-ray diffraction | A, B | — | — |
| 3N56 | Crystal structure of human insulin-degrading enzyme (ide) in complex with human B-type natriuretic… | x-ray diffraction | A, B | — | — |
| 3N57 | Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic… | x-ray diffraction | A, B | — | — |
| 3N57 | Crystal structure of human insulin-degrading enzyme (ide) in complex with human atrial natriuretic… | x-ray diffraction | A, B | — | — |
| 3OFI | Crystal structure of human insulin-degrading enzyme in complex with ubiquitin | x-ray diffraction | A, B | — | — |
| 3OFI | Crystal structure of human insulin-degrading enzyme in complex with ubiquitin | x-ray diffraction | A, B | — | — |
| 3QZ2 | The structure of cysteine-free human insulin degrading enzyme | x-ray diffraction | A, B | — | — |
| 3QZ2 | The structure of cysteine-free human insulin degrading enzyme | x-ray diffraction | A, B | — | — |
| 4DTT | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | x-ray diffraction | A, B | — | — |
| 4DTT | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | x-ray diffraction | A, B | — | — |
| 4DWK | Structure of cystein free insulin degrading enzyme with compound bdm41671… | x-ray diffraction | A, B | — | — |
| 4DWK | Structure of cystein free insulin degrading enzyme with compound BDM41671… | x-ray diffraction | A, B | — | — |
| 4GS8 | Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079… | x-ray diffraction | A, B | — | — |
| 4GS8 | Structure analysis of cysteine free insulin degrading enzyme (ide) with compound BDM43079… | x-ray diffraction | A, B | — | — |
| 4GSC | Structure analysis of insulin degrading enzyme with compound bdm41559… | x-ray diffraction | A, B | — | — |
| 4GSC | Structure analysis of insulin degrading enzyme with compound BDM41559… | x-ray diffraction | A, B | — | — |
| 4GSF | The structure analysis of cysteine free insulin degrading enzyme (ide) with… | x-ray diffraction | A, B | — | — |
| 4GSF | The structure analysis of cysteine free insulin degrading enzyme (ide) with… | x-ray diffraction | A, B | — | — |
| 4IFH | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 | x-ray diffraction | A, B | — | — |
| 4IFH | Crystal structure of human insulin degrading enzyme (ide) in complex with compound BDM44619 | x-ray diffraction | A, B | — | — |
| 4IOF | Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) | x-ray diffraction | A, B | — | — |
| 4IOF | Crystal structure analysis of Fab-bound human insulin degrading enzyme (ide) | x-ray diffraction | A, B | — | — |
| 4LTE | Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor | x-ray diffraction | A, B | — | — |
| 4LTE | Structure of cysteine-free human insulin degrading enzyme in complex with macrocyclic inhibitor | x-ray diffraction | A, B | — | — |
| 4M1C | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with… | x-ray diffraction | A, B | — | — |
| 4M1C | Crystal structure analysis of Fab-bound human insulin degrading enzyme (ide) in complex with… | x-ray diffraction | A, B | — | — |
| 4NXO | Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768 | x-ray diffraction | A, B | — | — |
| 4NXO | Crystal structure of insulin degrading enzyme in complex with BDM44768 | x-ray diffraction | A, B | — | — |
| 4PES | Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl… | x-ray diffraction | A, B | — | — |
| 4PES | Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl… | x-ray diffraction | A, B | — | — |
| 4PF7 | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4PF7 | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4PF9 | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4PF9 | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4PFC | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4PFC | Crystal structure of insulin degrading enzyme complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4QIA | Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor… | x-ray diffraction | A, B | — | — |
| 4QIA | Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor… | x-ray diffraction | A, B | — | — |
37 records more on the page itself.
Ligands
- ZN · Zinc ion · in 6 records
- J22 · {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol · in 2 records
- VQJ · 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide · in 2 records
- J18 · [(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-{[2-(trifluoromethyl)phenyl]sulfonyl}-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol · in 1 record
- VQD · (3R)-3-{4-[(3R)-4-(3,4-difluorobenzene-1-carbonyl) morpholin-3-yl]-1H-1,2,3-triazol-1-yl}-N-hydroxy-4-(naphthalen-2-yl)butanamide · in 1 record
- VQG · 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1, 2,3-triazol-4-yl}ethyl]benzamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.