Research workbench
Importin ALPHA2 in complex with P50 nls
Analyse Importin ALPHA2 in complex with P50 nls in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RG4
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Isoform 3 of nuclear factor nf-kappa-B P105 subunit
- UniProt
- P52293, P19838
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Importin subunit alpha-1 | protein | 427 | 72% helix, 0% strand | P52293 |
| B | Isoform 3 of nuclear factor nf-kappa-B P105 subunit | protein | 7 | 0% helix, 0% strand | P19838 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.46 | 0.82 | 13 | empty |
Interfaces
1 interface between chains.
- E–B · 722 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P19838
- Elsewhere: RCSB PDB 7RG4 · PDBe 7RG4 · UniProt P52293 · UniProt P19838
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