Research workbench
Crystal structure of leukemia inhibitory factor in complex with GP130
Analyse Crystal structure of leukemia inhibitory factor in complex with GP130 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1PVH
- Type
- protein
- Length
- 740 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-6 receptor beta chain; Leukemia inhibitory factor
- UniProt
- P40189, P15018
- Ligands
- IOD
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Interleukin-6 receptor beta chain | protein | 201 | 6% helix, 43% strand | P40189 |
| B, D | Leukemia inhibitory factor | protein | 169 | 65% helix, 0% strand | P15018 |
Ligands and binding sites
- IOD · Iodide ion · ion · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.58 | 0.83 | 25 | empty |
| 2 | 140 | 0.58 | 0.83 | 23 | empty |
| 3 | 235 | 0.53 | 0.76 | 23 | empty |
| 4 | 228 | 0.52 | 0.76 | 26 | empty |
| 5 | 79 | 0.41 | 0.78 | 19 | empty |
Interfaces
2 interfaces between chains.
- C–D · 737 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 733 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1PVH · Crystal structure of leukemia inhibitory factor in complex with gp130 · the same entry in another collection · chain A against A, TM-score 1.00
- P40189 · AlphaFold monomer V2.0 prediction for interleukin-6 receptor subunit beta (P40189) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P15018 · AlphaFold monomer V2.0 prediction for leukemia inhibitory factor (P15018) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40189
- Every structure of UniProt P15018
- Elsewhere: RCSB PDB 1PVH · PDBe 1PVH · UniProt P40189 · UniProt P15018
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