UniProt P40189
Interleukin-6 receptor subunit beta (P40189)
Interleukin-6 receptor subunit beta (UniProt P40189): 29 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 101 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P40189
- Protein
- Interleukin-6 receptor subunit beta
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 101 · 11 records with a druggable one
Structures
30 records of P40189 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BJ8 | Third N-terminal domain of GP130, NMR, minimized average structure | solution nmr | A | — | — |
| 1BJ8 | Third N-terminal domain of GP130, NMR, minimized average structure | solution nmr | A | — | — |
| 1BQU | Cytokyne-binding region of GP130 | x-ray diffraction | A, B | — | — |
| 1BQU | Cytokyne-binding region of GP130 | x-ray diffraction | A, B | — | — |
| 1I1R | Crystal structure of a CYTOKINE/RECEPTOR complex | x-ray diffraction | A | — | — |
| 1I1R | Crystal structure of a CYTOKINE/RECEPTOR complex | x-ray diffraction | A | — | — |
| 1P9M | Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex | x-ray diffraction | A | — | — |
| 1P9M | Crystal structure of the hexameric human il-6/IL-6 alpha RECEPTOR/GP130 complex | x-ray diffraction | A | — | — |
| 1PVH | Crystal structure of leukemia inhibitory factor in complex with gp130 | x-ray diffraction | A, C | — | — |
| 1PVH | Crystal structure of leukemia inhibitory factor in complex with GP130 | x-ray diffraction | A, C | — | — |
| 3L5H | Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly… | x-ray diffraction | A | — | — |
| 3L5H | Crystal structure of the full ectodomain of human GP130: new insights into the molecular assembly… | x-ray diffraction | A | — | — |
| 3L5I | Crystal structure of FnIII domains of human GP130 (Domains 4-6) | x-ray diffraction | A | — | — |
| 3L5I | Crystal structure of fniii domains of human GP130 (domains 4-6) | x-ray diffraction | A | — | — |
| 3L5J | Crystal structure of FnIII domains of human GP130 (Domains 4-6) | x-ray diffraction | A, B | — | — |
| 3L5J | Crystal structure of fniii domains of human GP130 (domains 4-6) | x-ray diffraction | A, B | — | — |
| 7U7N | IL-27 quaternary receptor signaling complex | electron microscopy | B | NAG | 4 (best 0.67) |
| 7U7N | Il-27 quaternary receptor signaling complex | electron microscopy | B | NAG | — |
| 8D6A | Cryo-EM structure of human LIF signaling complex: model containing the interaction core region | electron microscopy | A | NAG | 6 (best 0.69) |
| 8D74 | Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region | electron microscopy | A | NAG | 5 (best 0.68) |
| 8D7R | Cryo-EM structure of human CLCF1 signaling complex: model containing the interaction core region | electron microscopy | A | NAG | 5 (best 0.65) |
| 8D82 | Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular… | electron microscopy | A, E | NAG | 18 (best 0.81) |
| 8D85 | Cryo-EM structure of human IL-27 signaling complex: model containing the interaction core region | electron microscopy | B | NAG | 4 (best 0.72) |
| 8DPS | The structure of the interleukin 11 signalling complex, truncated gp130 | electron microscopy | A, D | NAG | 11 (best 0.68) |
| 8DPT | The structure of the IL-11 signalling complex, with full-length extracellular gp130 | electron microscopy | A, D | NAG | 16 (best 0.76) |
| 8DPU | The crystal structure of the IL-11 signalling complex | x-ray diffraction | A, D, G, J, M, P | NAG | 20 (best 0.78) |
| 8UPA | Structure of gp130 in complex with a de novo designed IL-6 mimetic | x-ray diffraction | B, D | NAG, PO4 | 6 (best 0.44) |
| 8V29 | Cryo-EM structure of human type I OSM receptor complex: model for full extracellular assembly | electron microscopy | B | NAG | 4 (best 0.80) |
| 8V2A | Cryo-EM structure of human type I OSM receptor complex: model for assembly core region | electron microscopy | B | NAG | 2 (best 0.58) |
| P40189 | AlphaFold monomer V2.0 prediction for interleukin-6 receptor subunit beta (P40189) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3L5I chain A against the predicted model P40189: TM-score 0.98, RMSD 0.86 Å
- 3L5I chain A against the predicted model P40189: TM-score 0.98, RMSD 0.86 Å
- 8UPA chain D against the predicted model P40189: TM-score 0.98, RMSD 1.11 Å
- 8UPA chain B against the predicted model P40189: TM-score 0.98, RMSD 1.03 Å
- 1PVH chain A against the predicted model P40189: TM-score 0.98, RMSD 0.91 Å
- 1PVH chain A against the predicted model P40189: TM-score 0.98, RMSD 0.91 Å
- 3L5J chain B against the predicted model P40189: TM-score 0.97, RMSD 1.15 Å
- 3L5J chain B against the predicted model P40189: TM-score 0.97, RMSD 1.15 Å
- 8V2A chain B against the predicted model P40189: TM-score 0.97, RMSD 0.97 Å
- 8D74 chain A against the predicted model P40189: TM-score 0.96, RMSD 1.55 Å
Elsewhere
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