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Aeronamide N-methyltransferase, aere (Y137F)

Analyse Aeronamide N-methyltransferase, aere (Y137F) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RC3
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methyltransferase family protein
UniProt: A0A329B7M1
Ligands: ASP, SAH, NA, CA
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase family protein	protein	374	41% helix, 24% strand	A0A329B7M1

Ligands and binding sites

ASP · Aspartic acid · ligand · chains A
SAH · S-adenosyl-L-homocysteine · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
CA · Calcium ion · metal · chains A
PG4 · Tetraethylene glycol · additive · chains A
PGE · Triethylene glycol · additive · chains A
P6G · Hexaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	640	0.75	0.81	72	PGE, SAH, NA
2	53	0.30	0.76	13	empty

Compared structures

7RC3 · Aeronamide N-methyltransferase, AerE (Y137F) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A329B7M1
Elsewhere: RCSB PDB 7RC3 · PDBe 7RC3 · UniProt A0A329B7M1

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