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Crystal structure of lactose permease with tdg
Analyse Crystal structure of lactose permease with tdg in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1PV7
- Type
- protein
- Length
- 834 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactose permease
- UniProt
- P02920
- Ligands
- YIO, GAL
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lactose permease | protein | 417 | 82% helix, 0% strand | P02920 |
Ligands and binding sites
- YIO · 1-thio-beta-D-galactopyranose · ligand · 2 copies · chains A, B
- GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1044 | 0.82 | 0.82 | 87 | YIO, GAL |
| 2 | 768 | 0.80 | 0.83 | 53 | YIO, GAL |
| 3 | 660 | 0.73 | 0.79 | 74 | empty |
| 4 | 220 | 0.63 | 0.82 | 34 | empty |
| 5 | 56 | 0.55 | 0.89 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 422 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02920
- Elsewhere: RCSB PDB 1PV7 · PDBe 1PV7 · UniProt P02920
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