Crystal structure of P300 CH1 domain in complex with citif (a CITED2- hif-1ALPHA hybrid)

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 0% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• B–A · 2331 Ų buried · 17 hydrogen bonds · protein-protein

Compared structures

• 7QGS · Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) · the same entry in another collection · chain B against B, TM-score 1.00
• Q99967 · AlphaFold monomer V2.0 prediction for CBP/P300-interacting transactivator 2 (Q99967) · a predicted model of the same protein · chain B against A, TM-score 0.44
• Q16665 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha (Q16665) · a predicted model of the same protein · chain B against A, TM-score 0.36

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q99967
• Every structure of UniProt Q16665
• Every structure of UniProt Q7Z6C1
• Elsewhere: RCSB PDB 7QGS · PDBe 7QGS · UniProt Q99967 · UniProt Q16665 · UniProt Q7Z6C1