Research workbench
Crystal structure of a mutant (P393GX) thyroid receptor alpha ligand binding domain designed to model dominant negative human mutations.
Analyse Crystal structure of a mutant (P393GX) thyroid receptor alpha ligand binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QDT
- Type
- protein
- Length
- 236 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform alpha-1 of thyroid hormone receptor alpha
- UniProt
- P10827
- Ligands
- T3
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform alpha-1 of thyroid hormone receptor alpha | protein | 236 | 61% helix, 6% strand | P10827 |
Ligands and binding sites
- T3 · 3,5,3'triiodothyronine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.79 | 0.92 | 39 | T3 |
| 2 | 144 | 0.46 | 0.77 | 21 | empty |
| 3 | 53 | 0.41 | 0.82 | 16 | empty |
Compared structures
- 7QDT · Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain… · the same entry in another collection · chain A against A, TM-score 1.00
- P10827 · AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P10827) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10827
- Elsewhere: RCSB PDB 7QDT · PDBe 7QDT · UniProt P10827
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