MolNFT v1 · #462618 · protein
AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P10827)
P10827: “AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P10827)”. 6 pockets (best druggability 0.82). MolNFT v1 #462618 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P10827
- Type
- protein
- Length
- 490 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Thyroid hormone receptor alpha
- UniProt
- P10827
- Pockets
- 6 · best druggability 0.82
Structure
1 distinct chain · 48% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroid hormone receptor alpha | protein | 490 | 48% helix, 4% strand | P10827 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.82 | 0.96 | 31 | empty |
| 2 | 278 | 0.58 | 0.78 | 32 | empty |
| 3 | 118 | 0.43 | 0.77 | 20 | empty |
| 4 | 116 | 0.42 | 0.76 | 25 | empty |
| 5 | 88 | 0.41 | 0.78 | 18 | empty |
Compared structures
- 8RQO · Human thyroid hormone receptor alpha ligand binding domain in complex with beta-selective… · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 4LNW · Crystal structure of TR-alpha bound to T3 in a second site · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 4LNW · Crystal structure of tr-alpha bound to T3 in a second site · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 4LNX · Crystal structure of tr-alpha bound to T4 in a second site · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 4LNX · Crystal structure of TR-alpha bound to T4 in a second site · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 1NAV · Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1 · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 1NAV · Thyroid receptor alpha in complex with an agonist selective for thyroid receptor BETA1 · an experimental structure of the same protein · chain A against A, TM-score 0.48
- 7QDT · Crystal structure of a mutant (P393GX) thyroid receptor alpha ligand binding domain… · an experimental structure of the same protein · chain A against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10827
- Elsewhere: UniProt P10827 · AlphaFold DB P10827
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