UniProt P10827
Isoform Alpha-1 of Thyroid hormone receptor alpha (P10827)
Isoform Alpha-1 of Thyroid hormone receptor alpha (UniProt P10827): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P10827
- Protein
- Isoform Alpha-1 of Thyroid hormone receptor alpha
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 14 · 3 records with a druggable one
Structures
10 records of P10827 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NAV | Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1 | x-ray diffraction | A | — | — |
| 1NAV | Thyroid receptor alpha in complex with an agonist selective for thyroid receptor BETA1 | x-ray diffraction | A | — | — |
| 4LNW | Crystal structure of TR-alpha bound to T3 in a second site | x-ray diffraction | A | — | — |
| 4LNW | Crystal structure of tr-alpha bound to T3 in a second site | x-ray diffraction | A | — | — |
| 4LNX | Crystal structure of TR-alpha bound to T4 in a second site | x-ray diffraction | A | — | — |
| 4LNX | Crystal structure of tr-alpha bound to T4 in a second site | x-ray diffraction | A | — | — |
| 7QDT | Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to… | x-ray diffraction | A | T3 | 3 (best 0.79) |
| 7QDT | Crystal structure of a mutant (P393GX) thyroid receptor alpha ligand binding domain designed to… | x-ray diffraction | A | T3 | — |
| 8RQO | Human thyroid hormone receptor alpha ligand binding domain in complex with beta-selective agonist… | x-ray diffraction | A | A1H2J, SO4 | 5 (best 0.82) |
| P10827 | AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P10827) | predicted | A | — | 6 (best 0.82) |
Ligands
Experiment against prediction
- 7QDT chain A against the predicted model P10827: TM-score 0.96, RMSD 1.37 Å
- 7QDT chain A against the predicted model P10827: TM-score 0.96, RMSD 1.37 Å
- 8RQO chain A against the predicted model P10827: TM-score 0.90, RMSD 2.12 Å
- 1NAV chain A against the predicted model P10827: TM-score 0.90, RMSD 2.23 Å
- 1NAV chain A against the predicted model P10827: TM-score 0.90, RMSD 2.23 Å
- 4LNW chain A against the predicted model P10827: TM-score 0.88, RMSD 2.35 Å
- 4LNX chain A against the predicted model P10827: TM-score 0.88, RMSD 2.33 Å
- 4LNW chain A against the predicted model P10827: TM-score 0.87, RMSD 2.42 Å
- 4LNX chain A against the predicted model P10827: TM-score 0.87, RMSD 2.33 Å
Elsewhere
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