Research workbench
Crystal structure of human METTL1 bound to sinefungin
Analyse Crystal structure of human METTL1 bound to sinefungin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PL1
- Type
- protein
- Length
- 210 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (guanine-N(7)-)-methyltransferase
- EC
- 2.1.1.33, 2.1.1.-
- UniProt
- Q9UBP6
- Ligands
- SFG, SO4
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33, 2.1.1.-) | protein | 210 | 35% helix, 22% strand | Q9UBP6 |
Ligands and binding sites
- SFG · Sinefungin · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.49 | 0.76 | 30 | SFG |
| 2 | 73 | 0.38 | 0.77 | 18 | GOL |
Compared structures
- 7PL1 · Crystal structure of human METTL1 bound to Sinefungin · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBP6 · AlphaFold monomer V2.0 prediction for tRNA (guanine-N(7)-)-methyltransferase (Q9UBP6) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBP6
- Elsewhere: RCSB PDB 7PL1 · PDBe 7PL1 · UniProt Q9UBP6
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