Research workbench
Solution structure of isolated drosophila histone H2A-H2B heterodimer
Analyse Solution structure of isolated drosophila histone H2A-H2B heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PJ1
- Type
- protein
- Length
- 245 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H2A; Histone H2B
- UniProt
- P84051, P02283
- Pockets
- 2 · best druggability 0.71
Structure
solution nmr · 2 distinct chains · 49% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H2A | protein | 123 | 41% helix, 3% strand | P84051 |
| B | Histone H2B | protein | 122 | 57% helix, 3% strand | P02283 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.71 | 0.84 | 38 | empty |
| 2 | 105 | 0.37 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2787 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 7PJ1 · Solution structure of isolated Drosophila histone H2A-H2B heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- P02283 · AlphaFold monomer V2.0 prediction for histone H2B (P02283) · a predicted model of the same protein · chain B against A, TM-score 0.67
- P84051 · AlphaFold monomer V2.0 prediction for histone H2A (P84051) · a predicted model of the same protein · chain A against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84051
- Every structure of UniProt P02283
- Elsewhere: RCSB PDB 7PJ1 · PDBe 7PJ1 · UniProt P84051 · UniProt P02283
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