Research workbench
Low resolution cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3
Analyse Low resolution cryo-EM structure of the full-length insulin receptor bound to 2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PG4
- Type
- protein
- Length
- 1,698 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform short of insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 11% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 786 | 8% helix, 32% strand | P06213 |
| B | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 822 | 12% helix, 27% strand | P06213 |
| C, I | Insulin | protein | 21 | 57% helix, 0% strand | P01308 |
| D | Insulin | protein | 25 | 36% helix, 0% strand | P01308 |
| J | Insulin | protein | 23 | 43% helix, 4% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.85 | 0.91 | 56 | empty |
| 2 | 286 | 0.84 | 0.94 | 54 | empty |
| 3 | 189 | 0.82 | 0.95 | 42 | empty |
| 4 | 97 | 0.76 | 0.96 | 35 | empty |
| 5 | 884 | 0.68 | 0.74 | 66 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2589 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 604 Ų buried · 7 hydrogen bonds · protein-protein
- I–J · 593 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 549 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 436 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 44 disulfide (disulfide).
Compared structures
- 7PG4 · Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7PG4 · PDBe 7PG4 · UniProt P06213 · UniProt P01308
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