Research workbench
Cryo-EM structure of PDR5 from saccharomyces cerevisiae in inward- facing conformation without nucleotides
Analyse Cryo-EM structure of PDR5 from saccharomyces cerevisiae in inward- facing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7P03
- Type
- protein
- Length
- 1,333 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pleiotropic ABC efflux transporter of multiple drugs
- UniProt
- P33302
- Pockets
- 12 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pleiotropic ABC efflux transporter of multiple drugs | protein | 1333 | 53% helix, 11% strand | P33302 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1158 | 0.82 | 0.83 | 78 | empty |
| 2 | 172 | 0.78 | 0.94 | 33 | empty |
| 3 | 615 | 0.75 | 0.81 | 37 | empty |
| 4 | 818 | 0.74 | 0.79 | 88 | empty |
| 5 | 239 | 0.70 | 0.86 | 40 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7P03 · Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation… · the same entry in another collection · chain A against A, TM-score 1.00
- P33302 · AlphaFold monomer V2.0 prediction for pleiotropic ABC efflux transporter of multiple… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33302
- Elsewhere: RCSB PDB 7P03 · PDBe 7P03 · UniProt P33302
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