MolNFT v1 · #291055 · protein
AlphaFold monomer V2.0 prediction for pleiotropic ABC efflux transporter of multiple drugs (P33302)
P33302: “AlphaFold monomer V2.0 prediction for pleiotropic ABC efflux transporter of multiple drugs (P33302)”. 20 pockets (best druggability 0.84). MolNFT v1 #291055 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P33302
- Type
- protein
- Length
- 1,511 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xC416EAe88162fE5e5FCc9C720A60b7eb703e7AfD
- Molecule
- Pleiotropic ABC efflux transporter of multiple drugs
- UniProt
- P33302
- Pockets
- 20 · best druggability 0.84
Structure
1 distinct chain · 52% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pleiotropic ABC efflux transporter of multiple drugs | protein | 1511 | 52% helix, 11% strand | P33302 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 562 | 0.84 | 0.89 | 48 | empty |
| 2 | 360 | 0.80 | 0.90 | 52 | empty |
| 3 | 398 | 0.80 | 0.89 | 46 | empty |
| 4 | 307 | 0.79 | 0.90 | 61 | empty |
| 5 | 852 | 0.77 | 0.80 | 62 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7P06 · Cryo-EM structure of PDR5 from saccharomyces cerevisiae in outward- facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 7P06 · Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 7P04 · Cryo-EM structure of PDR5 from saccharomyces cerevisiae in inward- facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 7P04 · Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 7P05 · Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 7P05 · Cryo-EM structure of PDR5 from saccharomyces cerevisiae in inward- facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 7P03 · Cryo-EM structure of PDR5 from saccharomyces cerevisiae in inward- facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 7P03 · Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation… · an experimental structure of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33302
- Elsewhere: UniProt P33302 · AlphaFold DB P33302
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.