Research workbench
Structure of the human UFC1 protein in complex with the UBA5 C- terminal UFC1-binding motif.
Analyse Structure of the human UFC1 protein in complex with the UBA5 C- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OVC
- Type
- protein
- Length
- 194 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-fold modifier-conjugating enzyme 1; Ubiquitin-like modifier-activating enzyme 5
- UniProt
- Q9Y3C8, Q9GZZ9
- Pockets
- 2 · best druggability 0.42
Structure
solution nmr · 2 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-fold modifier-conjugating enzyme 1 | protein | 167 | 42% helix, 16% strand | Q9Y3C8 |
| B | Ubiquitin-like modifier-activating enzyme 5 | protein | 27 | 41% helix, 0% strand | Q9GZZ9 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.42 | 0.74 | 20 | empty |
| 2 | 56 | 0.31 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1085 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7OVC · Structure of the human UFC1 protein in complex with the UBA5 C-terminal UFC1-binding… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y3C8 · AlphaFold monomer V2.0 prediction for ubiquitin-fold modifier- conjugating enzyme 1… · a predicted model of the same protein · chain A against A, TM-score 0.87
- Q9GZZ9 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 5… · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3C8
- Every structure of UniProt Q9GZZ9
- Elsewhere: RCSB PDB 7OVC · PDBe 7OVC · UniProt Q9Y3C8 · UniProt Q9GZZ9
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